Can molecular mimicry explain the cytokine storm of SARS-CoV-2?: An in silico approach

被引：12

作者：

Obando-Pereda, Gustavo ^{[1
]}

机构：

[1] Univ Catolica Santa Maria, Prote Inflammat & Pain Lab, Urb San Jose S-N, Arequipa 04001, Peru

来源：

JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 09期

关键词：

cytokine storm; macrophage; molecular mimicry; SARS-CoV-2; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; MACROPHAGE ACTIVATION; CD8(+) T; COVID-19; PROTEIN; PARP14; SEQUENCE; PEPTIDE;

D O I：

10.1002/jmv.27040

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients.

引用

页码：5350 / 5357

页数：8

共 50 条

[21] The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection
Copaescu, Ana
Smibert, Olivia
Gibson, Andrew
Phillips, Elizabeth J.
Trubiano, Jason A.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 146 (03) : 518 - +
[22] Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells
Hafezi, Bahareh
Chan, Lily
Knapp, Jason P.
Karimi, Negar
Alizadeh, Kimia
Mehrani, Yeganeh
Bridle, Byram W.
Karimi, Khalil
CELLS, 2021, 10 (07)
[23] Glucosinolates and their hydrolysis products as potential nutraceuticals to combat cytokine storm in SARS-COV-2
Bahoosh, Saba Rahimi
Shokoohinia, Yalda
Eftekhari, Mahdieh
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 30 (01) : 245 - 252
[24] Comparison of the Characteristics of Cytokine Storm and Immune Response Induced by SARS-CoV, MERS-CoV, and SARS-CoV-2 Infections
Liu, Tong
Feng, Meng
Wen, Zexin
He, Yijie
Lin, Wei
Zhang, Min
JOURNAL OF INFLAMMATION RESEARCH, 2021, 14 : 5475 - 5487
[25] Molecular Docking Analysis of the Phytochemicals from Tinospora Cordifolia as Potential Inhibitor Against Multi Targeted SARS-CoV-2 & Cytokine Storm
Panigrahi, Debadash
JOURNAL OF COMPUTATIONAL BIOPHYSICS AND CHEMISTRY, 2021, 20 (06): : 559 - 580
[26] Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations
Thepmankorn, Parisorn
Bach, John
Lasfar, Ahmed
Zhao, Xilin
Souayah, Sami
Chong, Zhao Zhong
Souayah, Nizar
CYTOKINE, 2021, 138
[27] Can alpha-linolenic acid be a modulator of "cytokine storm," oxidative stress and immune response in SARS-CoV-2 infection?
Cianciosi, Danila
Diaz, Yasmany Armas
Gaddi, Antonio Vittorino
Capello, Fabio
Savo, Maria Teresa
Casanova, Ramon del Jesus Pali
Espinosa, Julio Cesar Martinez
Barrera, Alina Eugenia Pascual
Navarro-Hortal, Maria-Dolores
Tian, Lingmin
Bai, Weibin
Giampieri, Francesca
Battino, Maurizio
FOOD FRONTIERS, 2024, 5 (01): : 73 - 93
[28] Cytokines and Chemokines in SARS-CoV-2 Infections-Therapeutic Strategies Targeting Cytokine Storm
Pum, Alexandra
Ennemoser, Maria
Adage, Tiziana
Kungl, Andreas J.
BIOMOLECULES, 2021, 11 (01) : 1 - 21
[29] Cytokine storm and colchicine potential role in fighting SARS-CoV-2 pneumonia
Vitiello, Antonio
Ferrara, Francesco
Pelliccia, Chiara
Granata, Giovanni
La Porta, Raffaele
ITALIAN JOURNAL OF MEDICINE, 2020, 14 (02) : 88 - 94
[30] Role of epinephrine in attenuating cytokine storm, decreasing ferritin, and inhibiting ferroptosis in SARS-CoV-2
EL-Molla, Ashraf
Fetouh, Fawzia Aboul
Bawazir, Samir
Ali, Yasser
Alwahby, Yehya
Bahadeg, Muhammad
Gotah, Yousef
Badahdah, Fatima Ahmed
Alsaeed, Abdullatif H.
Basseet, Abdullah
EGYPTIAN HEART JOURNAL, 2024, 76 (01)

← 1 2 3 4 5 →