Can molecular mimicry explain the cytokine storm of SARS-CoV-2?: An in silico approach

被引：12
|
作者：
Obando-Pereda, Gustavo [1 ]
机构：
[1] Univ Catolica Santa Maria, Prote Inflammat & Pain Lab, Urb San Jose S-N, Arequipa 04001, Peru
来源：
JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 09期
关键词：
cytokine storm; macrophage; molecular mimicry; SARS-CoV-2; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; MACROPHAGE ACTIVATION; CD8(+) T; COVID-19; PROTEIN; PARP14; SEQUENCE; PEPTIDE;
D O I：
10.1002/jmv.27040
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients.
引用
收藏
页码：5350 / 5357
页数：8
相关论文
共 50 条
  • [1] Cytokine storm induced by SARS-CoV-2
    Song, Peipei
    Li, Wei
    Xie, Jianqin
    Hou, Yanlong
    You, Chongge
    CLINICA CHIMICA ACTA, 2020, 509 : 280 - 287
  • [2] Cytokine storm syndrome in SARS-CoV-2: a review
    Wahid, Braira
    Rani, Noshaba
    Idrees, Muhammad
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2022, 77 (1-2): : 65 - 69
  • [3] Triamcinolone as a Potential Inhibitor of SARS-CoV-2 Main Protease and Cytokine Storm: An In silico Study
    Mishra, Amaresh
    Qais, Faizan Abul
    Pathak, Yamini
    Camps, Ihosvany
    Tripathi, Vishwas
    LETTERS IN DRUG DESIGN & DISCOVERY, 2023, 20 (09) : 1230 - 1242
  • [4] SARS-CoV-2: Cytokine Storm and Therapy
    Sajid, Mir Ibrahim
    Tariq, Javeria
    Awais, Shehar Bano
    Naseem, Zehra
    Balouch, Samira Shabbir
    Abaidullah, Sajid
    ANNALS OF KING EDWARD MEDICAL UNIVERSITY LAHORE PAKISTAN, 2020, 26 : 243 - 251
  • [5] From Anti-SARS-CoV-2 Immune Response to the Cytokine Storm via Molecular Mimicry
    Kanduc, Darja
    ANTIBODIES, 2021, 10 (04)
  • [6] Molecular mimicry between SARS-CoV-2 and the female reproductive system
    Dotan, Arad
    Kanduc, Darja
    Muller, Sylviane
    Makatsariya, Alexander
    Shoenfeld, Yehuda
    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2021, 86 (06)
  • [7] Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm
    Rabiu Abubakar, Abdullahi
    Ahmad, Rahnuma
    Rowaiye, Adekunle Babajide
    Rahman, Sayeeda
    Iskandar, Katia
    Dutta, Siddhartha
    Oli, Angus Nnamdi
    Dhingra, Sameer
    Tor, Maryam Abba
    Etando, Ayukafangha
    Kumar, Santosh
    Irfan, Mohammed
    Gowere, Marshall
    Chowdhury, Kona
    Akter, Farhana
    Jahan, Dilshad
    Schellack, Natalie
    Haque, Mainul
    LIFE-BASEL, 2022, 12 (04):
  • [8] SARS-CoV-2 and human retroelements: a case for molecular mimicry?
    Koch, Benjamin Florian
    BMC GENOMIC DATA, 2022, 23 (01):
  • [9] Promising drug repurposing approach targeted for cytokine storm implicated in SARS-CoV-2 complications
    Shawki, May Ahmed
    Elsayed, Noha Salah
    Mantawy, Eman M.
    Said, Riham S.
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021, 43 (04) : 395 - 409
  • [10] Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2
    Gour, Abhishek
    Manhas, Diksha
    Bag, Swarnendu
    Gorain, Bapi
    Nandi, Utpal
    PHYTOTHERAPY RESEARCH, 2021, 35 (08) : 4258 - 4283
12345