Lipid bilayer stress in obesity-linked inflammatory and metabolic disorders

被引:39
作者
Gianfrancesco, Marco A. [1 ,2 ]
Paquot, Nicolas [1 ,2 ]
Pierre, Jacques [3 ]
Legrand-Poels, Sylvie [1 ,3 ]
机构
[1] Univ Liege, Lab Immunometab & Nutr, GIGA I3, Liege, Belgium
[2] Univ Hosp Liege, Dept Med, Div Diabet Nutr & Metab Disorders, Liege, Belgium
[3] Univ Liege, Lab Virol & Immunol, GIGA Mol Biol Dis, Liege, Belgium
关键词
Membrane; Lipid; ER stress; Metabolism; Obesity; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; UNSATURATED FATTY-ACIDS; DE-NOVO LIPOGENESIS; TOLL-LIKE RECEPTORS; NA+; K+-ATPASE ALPHA-SUBUNIT; HUMAN TISSUE NA; K-ATPASE; NLRP3; INFLAMMASOME; PLASMA-MEMBRANE; CRYSTAL-STRUCTURE;
D O I
10.1016/j.bcp.2018.02.022
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The maintenance of the characteristic lipid compositions and physicochemical properties of biological membranes is essential for their proper function. Mechanisms allowing to sense and restore membrane homeostasis have been identified in prokaryotes for a long time and more recently in eukaryotes. A membrane remodeling can result from aberrant metabolism as seen in obesity. In this review, we describe how such lipid bilayer stress can account for the modulation of membrane proteins involved in the pathogenesis of obesity-linked inflammatory and metabolic disorders. We address the case of the Toll-like receptor 4 that is implicated in the obesity-related low grade inflammation and insulin resistance. The lipid raft-mediated TLR4 activation is promoted by an enrichment of the plasma membrane with saturated lipids or cholesterol increasing the lipid phase order. We discuss of the plasma membrane Na, K-ATPase that illustrates a new concept according to which direct interactions between specific residues and particular lipids determine both stability and activity of the pump in parallel with indirect effects of the lipid bilayer. The closely related sarco(endo)-plasmic Ca-ATPase embedded in the more fluid ER membrane seems to be more sensitive to a lipid bilayer stress as demonstrated by its inactivation in cholesterol-loaded macrophages or its inhibition mediated by an increased PtdCho/PtdEtn ratio in obese mice hepatocytes. Finally, we describe the model recently proposed for the activation of the conserved IRE-1 protein through alterations in the ER membrane lipid packing and thickness. Such IRE-1 activation could occur in response to abnormal lipid synthesis and membrane remodeling as observed in hepatocytes exposed to excess nutrients. Since the IRE-1/XBP1 branch also stimulates the lipid synthesis, this pathway could create a vicious cycle "lipogenesis-ER lipid bilayer stress-lipogenesis" amplifying hepatic ER pathology and the obesity linked systemic metabolic defects.
引用
收藏
页码:168 / 183
页数:16
相关论文
共 234 条
[1]   Fatty acid composition of membrane bilayers: Importance of diet polyunsaturated fat balance [J].
Abbott, Sarah K. ;
Else, Paul L. ;
Atkins, Taleitha A. ;
Hulbert, A. J. .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2012, 1818 (05) :1309-1317
[2]   Transcriptional control of the low-temperature-inducible des gene, encoding the Δ5 desaturase of Bacillus subtilis [J].
Aguilar, PS ;
Lopez, P ;
De Mendoza, D .
JOURNAL OF BACTERIOLOGY, 1999, 181 (22) :7028-7033
[3]   Insight into the putative specific interactions between cholesterol, sphingomyelin, and palmitoyl-oleoyl phosphatidylcholine [J].
Aittoniemi, Jussi ;
Niemela, Perttu S. ;
Hyvonen, Marja T. ;
Karttunen, Mikko ;
Vattulainen, Ilpo .
BIOPHYSICAL JOURNAL, 2007, 92 (04) :1125-1137
[4]   Pathogen recognition and innate immunity [J].
Akira, S ;
Uematsu, S ;
Takeuchi, O .
CELL, 2006, 124 (04) :783-801
[5]   The membrane fluidity sensor DesK of Bacillus subtilis controls the signal decay of its cognate response regulator [J].
Albanesi, D ;
Mansilla, MC ;
de Mendoza, D .
JOURNAL OF BACTERIOLOGY, 2004, 186 (09) :2655-2663
[6]   Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J].
Alberti, K. G. M. M. ;
Eckel, Robert H. ;
Grundy, Scott M. ;
Zimmet, Paul Z. ;
Cleeman, James I. ;
Donato, Karen A. ;
Fruchart, Jean-Charles ;
James, W. Philip T. ;
Loria, Catherine M. ;
Smith, Sidney C., Jr. .
CIRCULATION, 2009, 120 (16) :1640-1645
[7]   The Bacillus subtilis acyl lipid desaturase is a Δ5 desaturase [J].
Altabe, SG ;
Aguilar, P ;
Caballero, GM ;
de Mendoza, D .
JOURNAL OF BACTERIOLOGY, 2003, 185 (10) :3228-3231
[8]   De nova lipogenesis in health and disease [J].
Ameer, Fatima ;
Scandiuzzi, Lisa ;
Hasnain, Shahida ;
Kalbacher, Hubert ;
Zaidi, Nousheen .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2014, 63 (07) :895-902
[9]   Fatty acid composition of skeletal muscle reflects dietary fat composition in humans [J].
Andersson, A ;
Nälsén, C ;
Tengblad, S ;
Vessby, B .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 76 (06) :1222-1229
[10]  
[Anonymous], 2008, Cambridge advanced learner's dictionary, V3rd