Upregulation of MALAT1 expression predicts a poor prognosis in the development of intracranial aneurysm (IA)

The aim of this study was to detect the role of serum MALAT1 expression levels in patients of intracranial aneurysm (IA) and identify its correlation with the development of IA. The 105 IA blood samples were collected from peripheral vein, and the control group was 40 healthy volunteers. Real-time PCR analysis was performed to detect the expression of MALAT1. Kaplan-Meier survival curves and long-rank test were used for survival analysis. Univariate and multivariate Cox proportional hazards regression analysis was performed to analyze the prognosis for intracranial aneurysm (IA) patients. In the study, our results showed that the MALAT1 expression in intracranial aneurysm (IA) patients was significantly higher MALAT1 expressions than that in the healthy volunteers. Furthermore, we found that MALAT1 expression was closely associations with hypertension history, rupture and Hunt-Hess level. Patients with higher MALAT1 expression had short disease-free survival (DFS) and poor overall survival (OS) than those with lower MALAT1 expression. Univariate and Multivariate Cox proportional hazards regression analysis revealed that MALAT1 expression, hypertension history, rupture and Hunt-Hess were independent risk factors for predicting the IA patient prognosis. Thus, our results demonstrated that serum MALAT1 expression in IA patients may be a novel predicted biomarker for prognosis.