Canine models for human genetic neurodegenerative diseases

被引：5

作者：

Barsoum, SC

Callahan, HM

Robinson, K

Chang, PL

机构：

[1] McMaster Univ, Hlth Sci Ctr, Dept Pediat, Hamilton, ON L8S 4J9, Canada

[2] McMaster Univ, Dept Biol, Hamilton, ON, Canada

[3] Univ Toronto, Dept Physiol & Pharmacol, Toronto, ON, Canada

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2000年 / 24卷 / 05期

关键词：

Alzheimer disease; cognitive tests; gene therapy; lysosomal storage disease; mucopolysaccharidosis;

D O I：

10.1016/S0278-5846(00)00108-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Canine models of human neurodegenerative disorders are uncommon. However, the similarity between canines and humans in body sizes and physiology provides an exceptional opportunity to use these models to study human diseases. 2. The authors will present a review on the neurological deficits that have been observed in canine models of genetic neurodegenerative diseases, and summarize the current gene therapy treatments being developed for some of these conditions.

引用

页码：811 / 823

页数：13

共 62 条

[1] Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients [J].