Can a Cure Be Achieved with Taxane-Based Chemotherapy plus Surgery in Patients with Primary Mediastinal Non-Seminomatous Germ Cell Tumors and Progression or Relapse Despite First-Line Chemotherapy?

被引:0
作者
Miskovska, Vera [1 ,2 ]
Levy, Antonin [1 ]
Massard, Christophe C. [1 ]
Gross-Goupil, Marine [1 ]
Bossi, Alberto [1 ]
Fizazi, Karim [1 ]
机构
[1] Inst Gustave Roussy, Dept Med, Villejuif, France
[2] St Elisabeth Canc Inst, Bratislava, Slovakia
来源
ONKOLOGIE | 2010年 / 33卷 / 03期
关键词
mediastinal non-seminomatous germ cell tumor; primary; Taxane; Relapse; CISPLATIN-BASED CHEMOTHERAPY; HIGH-DOSE CHEMOTHERAPY;
D O I
10.1159/000277824
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Primary mediastinal non-seminomatous germ cell tumors (NSCGTs) have a poor prognosis in the International Germ Cell Cancer Collaborative Group (IGCCCG) classification. There is no clear standard of treatment at relapse. Between 1995 and 2005, 13 patients experienced progression or relapse, and 1 patient was cured with a taxane-based chemotherapy plus surgical resection at our institution.
引用
收藏
页码:119 / 120
页数:2
相关论文
共 7 条
  • [1] Durable complete remission after weekly docetaxel administration in a patient with mediastinal non-seminomatous germ-cell tumor refractory to cisplatin-based chemotherapy
    Berruti, A
    Saini, A
    Gorzegno, G
    Tampellini, M
    Borasio, P
    Dogliotti, L
    [J]. ANNALS OF ONCOLOGY, 2003, 14 (10) : 1589 - 1590
  • [2] High-dose chemotherapy as salvage treatment in germ cell tumors: A Multivariate analysis of prognostic variables
    Beyer, J
    Kramar, A
    Mandanas, R
    Linkesch, W
    Greinix, A
    Droz, JP
    Pico, JL
    Diehl, A
    Bokemeyer, C
    Schmoll, HJ
    Nichols, CR
    Einhorn, LH
    Siegert, W
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (10) : 2638 - 2645
  • [3] Primary mediastinal nonseminomatous germ cell tumors:: Results of modern therapy including cisplatin-based chemotherapy
    Fizazi, K
    Culine, S
    Droz, JP
    Kramar, A
    Théodore, C
    Ruffié, P
    Le Chevalier, T
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (02) : 725 - 732
  • [4] Second-line chemotherapy in patients with relapsed extragonadal nonseminomatous germ cell tumors: Results of an international multicenter analysis
    Hartmann, JT
    Einhorn, L
    Nichols, CR
    Droz, JP
    Horwich, A
    Gerl, A
    Fossa, SD
    Beyer, J
    Pont, J
    Schmoll, HJ
    Kanz, L
    Bokemeyer, C
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (06) : 1641 - 1648
  • [5] Sequential high-dose chemotherapy protocol for relapsed poor prognosis germ cell tumors combining two mobilization and cytoreductive treatments followed by three high-dose chemotherapy regimens supported by autologous stem cell transplantation.: Results of the phase II multicentric TAXIF trial
    Lotz, JP
    Bui, B
    Gomez, F
    Théodore, C
    Caty, A
    Fizazi, K
    Gravis, G
    Delva, R
    Peny, J
    Viens, P
    Duclos, B
    De Revel, T
    Curé, H
    Gligorov, J
    Guillemaut, S
    Ségura, C
    Provent, S
    Droz, JP
    Culine, S
    Biron, P
    [J]. ANNALS OF ONCOLOGY, 2005, 16 (03) : 411 - 418
  • [6] Mead GM, 1997, J CLIN ONCOL, V15, P594
  • [7] SALVAGE CHEMOTHERAPY IN PATIENTS WITH EXTRAGONADAL NONSEMINOMATOUS GERM-CELL TUMORS - THE INDIANA-UNIVERSITY EXPERIENCE
    SAXMAN, SB
    NICHOLS, CR
    EINHORN, LH
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (07) : 1390 - 1393