Effect of Exercise on Brain-Derived Neurotrophic Factor in Stroke Survivors: A Systematic Review and Meta-Analysis

被引:18
作者
Ashcroft, Sarah K. [1 ]
Ironside, Daniel D. [1 ]
Johnson, Liam [2 ,3 ]
Kuys, Suzanne S. [4 ]
Thompson-Butel, Angelica G. [1 ]
机构
[1] Australian Catholic Univ, Sch Behav & Hlth Sci, 163-167 Albert Rd, Strathfield, NSW 2135, Australia
[2] Australian Catholic Univ, Sch Behav & Hlth Sci, Fitzroy, Vic, Australia
[3] Univ Melbourne, Melbourne Sch Hlth Sci, Parkville, Vic, Australia
[4] Australian Catholic Univ, Sch Allied Hlth, Banyo, Qld, Australia
关键词
brain-derived neurotrophic factor; exercise; neuroplasticity; rehabilitation; stroke; AEROBIC EXERCISE; ISCHEMIC-STROKE; BDNF; RECOVERY; SERUM; RECOMMENDATIONS;
D O I
10.1161/STROKEAHA.122.039919
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: BDNF (brain-derived neurotrophic factor) is a biomarker of neuroplasticity linked with better functional outcomes after stroke. Early evidence suggests that increased concentrations after exercise may be possible for people with stroke, however it is unclear how exercise parameters influence BDNF concentration. Methods: This systematic review and meta-analysis searched 7 electronic databases. Experimental or observational studies measuring changes in BDNF concentration after exercise in people poststroke were included. Data were extracted including characteristics of the study, participants, interventions, and outcomes. Several fixed and random effects meta-analyses were completed. Results: Seventeen studies including a total of 687 participants met the eligibility criteria (6 randomized trials). Significant improvements were observed in BDNF concentration following a single session (mean difference, 2.49 ng/mL; [95% CI, 1.10-3.88]) and program of high intensity aerobic exercise (mean difference, 3.42 ng/mL; [95% CI, 1.92-4.92]). Conclusions: High intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity. Registration: URL: https://www.crd.york.ac.uk/PROSPERO/; Unique identifier: CRD42021251083.
引用
收藏
页码:3706 / 3716
页数:11
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