Solid/liquid palladium-catalyzed coupling of haloaryls using alcohols as reducing agents: Kinetics and process optimization

被引：11

作者：

Gitis, D

Mukhopadhyay, S

Rothenberg, G

Sasson, Y ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Casali Inst Appl Chem, IL-91904 Jerusalem, Israel

[2] Univ Calif Berkeley, Dept Chem Engn, Berkeley, CA 94720 USA

[3] Univ Amsterdam, Dept Chem Engn, NL-1018 WV Amsterdam, Netherlands

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2003年 / 7卷 / 01期

关键词：

D O I：

10.1021/op015519+

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Heterogeneous Pd-catalyzed coupling reaction of substituted halobenzenes to biphenyls is performed effectively in different organic solvents using an alcohol as the reducing agent in the presence of a base and a catalytic amount of phase-transfer (PT) agent. The alcohol is oxidized to the respective aldehyde or ketone. Kinetic studies show that the reaction rate equation fits to second order in halobenzene. The effects of reaction temperature, catalyst loading, base concentration, PTC concentration, and alcohol concentration and structure are studied and discussed.

引用

页码：109 / 114

页数：6

共 41 条

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