Cytokine therapy restores antitumor responses of NK cells rendered anergic in MHC I-deficient tumors

被引：9

作者：

Ardolino, Michele

Raulet, David H. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA

来源：

ONCOIMMUNOLOGY | 2016年 / 5卷 / 01期

关键词：

cancer immunotherapy; cytokines; NK cells; NATURAL-KILLER-CELLS;

D O I：

10.1080/2162402X.2014.1002725

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent extraordinary advances in cancer immunotherapy rely primarily on marshaling T cell responses. Here we discuss how NK cell responses can be amplified. We find that MHC I-deficient tumors induce anergy of NK cells but that cytokine therapy restores NK cell activity and increases the survival of mice bearing MHC I-deficient tumors.

引用

页数：2

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