Cytokine therapy restores antitumor responses of NK cells rendered anergic in MHC I-deficient tumors

被引：8
|
作者：
Ardolino, Michele
Raulet, David H. [1 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA
来源：
ONCOIMMUNOLOGY | 2016年 / 5卷 / 01期
关键词：
cancer immunotherapy; cytokines; NK cells; NATURAL-KILLER-CELLS;
D O I：
10.1080/2162402X.2014.1002725
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent extraordinary advances in cancer immunotherapy rely primarily on marshaling T cell responses. Here we discuss how NK cell responses can be amplified. We find that MHC I-deficient tumors induce anergy of NK cells but that cytokine therapy restores NK cell activity and increases the survival of mice bearing MHC I-deficient tumors.
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页数：2
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