Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

被引：31
|
作者：
Cousins, Alex R. O. [1 ,2 ]
Ritson, Dougal [2 ]
Sharma, Pallavi [2 ]
Stevens, Malcolm F. G. [3 ]
Moses, John E. [2 ]
Searle, Mark S. [1 ,2 ]
机构：
[1] Univ Nottingham, Ctr Biomol Sci, Nottingham NG7 2RD, England
[2] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
[3] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 96期
关键词：
CATALYTIC SUBUNIT; SMALL-MOLECULE; C-MYC; BINDING; REGION;
D O I：
10.1039/c4cc07487d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)(n), n = 3, 7 and 11)) show that an oxazole-based 'click' ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.
引用
收藏
页码：15202 / 15205
页数：4
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