Studies on the narciclasine alkaloids: Total synthesis of (+)-narciclasine and (+)-pancratistatin

被引：153

作者：

Rigby, JH ^{[1
]}

Maharoof, USM ^{[1
]}

Mateo, ME ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 28期

关键词：

D O I：

10.1021/ja000930i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective total syntheses of the antitumor alkaloids. (+)-narciclasine and (+)-pancratistatin, are reported. These syntheses feature a stereo- and regiocontrolled aryl enamide photocyclization to construct a common, advanced intermediate possessing a trans-fused BC substructure. Differential functional group interchange in the C-ring of this phenanthridone core structure allows for the production of the two target natural products in enantiomerically pure form.

引用

页码：6624 / 6628

页数：5

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