Genetics of Human Sleep Behavioral Phenotypes

被引：16

作者：

Hsu, Pei-Ken ^{[1
,2
]}

Ptacek, Louis J. ^{[1
,2
]}

Fu, Ying-Hui ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA USA

来源：

CIRCADIAN RHYTHMS AND BIOLOGICAL CLOCKS, PT B | 2015年 / 552卷

关键词：

COPY-NUMBER VARIATION; PLURIPOTENT STEM-CELLS; MUTATION; DENSITY; CLOCK; DEPRIVATION; GENERATION; REPEAT; ADULT; MICE;

D O I：

10.1016/bs.mie.2014.10.046

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Quality sleep is critical for daily functions of human beings and thus the timing and duration of sleep are tightly controlled. However, rare genetic variants affecting sleep regulatory mechanisms can result in sleep phenotypes of extremely deviated sleep/wake onset time or duration. Using genetic analyses in families with multiple members expressing particular sleep phenotypes, these sleep-associated genetic variants can be identified. Deciphering the nature of these genetic variants using animal models or biochemical methods helps further our understanding of sleep processes. In this chapter, we describe the methods for studying genetics of human sleep behavioral phenotypes.

引用

页码：309 / 324

页数：16

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