Synthesis and Characterization of a Fluorescent Water-Soluble Paclitaxel Prodrug

被引：0

作者：

Sohn, Jeong-Sun ^{[2
]}

Choi, Eun-Sun ^{[1
]}

Jo, Byung-Wook ^{[1
]}

Hess, Michael ^{[1
,3
]}

Han, Song-Hee ^{[4
]}

机构：

[1] Chosun Univ, Dept Chem & Biochem Engn, Kwangju 501759, South Korea

[2] Chosun Univ, Dept Polymer Sci & Engn, Kwangju 501759, South Korea

[3] Univ Siegen, Dept Macromol Chem, D-57068 Siegen, Germany

[4] Mokpo Natl Maritime Univ, Div Liberal Arts & Sci, Jeonnam 530729, South Korea

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2010年 / 10卷 / 05期

关键词：

Water-Soluble Paclitaxel Prodrug (PP7); Fluorescent Probe; Synthesis; POLYMER-MODIFICATION; ANTICANCER DRUG; ALBUMIN; ACID;

D O I：

10.1166/jnn.2010.2241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A fluorescence susceptible water-soluble paclitaxel was synthesized by a condensation reaction between PEGylated paclitaxel (namely, PP7) and 1-pyrene butyric acid (PBA) in order to obtain a better understanding of the mechanism of action of paclitaxel as well as of the environment of the paclitaxel-binding site. The reaction was performed successfully and the resulting paclitaxel was characterized by FT-NMR, analytical-HPLC, UV spectro photometry, and fluorescence spectrometry. The synthesized paclitaxel analogue showed a high susceptibility to fluorescence in both excitation and emission spectra. And we have investigated the time-resolved fluorescence behavior of them in different solvents and at different excitation wavelengths.

引用

页码：3478 / 3483

页数：6

共 18 条

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