Microenvironmental M1 tumor-associated macrophage polarization influences cancer-related anemia in advanced ovarian cancer: key role of interleukin-6

被引:39
作者
Madeddu, Clelia [1 ]
Gramignano, Giulia [2 ]
Kotsonis, Paraskevas [3 ]
Coghe, Ferdinando [4 ]
Atzeni, Vinicio [5 ]
Scartozzi, Mario [4 ]
Maccio, Antonio [3 ]
机构
[1] Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy
[2] San Gavino Hosp, Med Oncol Unit, San Gavino, Italy
[3] Azienda Osped Brotzu, Dept Gynecol Oncol, Cagliari, Italy
[4] Azienda Osped Univ Cagliari, Lab Serv, Monserrato, Italy
[5] Azienda Osped Brotzu, Hosp Med Management, Cagliari, Italy
关键词
IRON; METABOLISM; INFLAMMATION; ACTIVATION; PHENOTYPE; HEPCIDIN; CELLS;
D O I
10.3324/haematol.2018.191551
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E388 / E391
页数:4
相关论文
共 15 条
[1]   Orchestration of Metabolism by Macrophages [J].
Biswas, Subhra K. ;
Mantovani, Alberto .
CELL METABOLISM, 2012, 15 (04) :432-437
[2]   Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm [J].
Biswas, Subhra K. ;
Mantovani, Alberto .
NATURE IMMUNOLOGY, 2010, 11 (10) :889-896
[3]   Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype [J].
Cairo, Gaetano ;
Recalcati, Stefania ;
Mantovani, Alberto ;
Locati, Massimo .
TRENDS IN IMMUNOLOGY, 2011, 32 (06) :241-247
[4]   Lactoferrin Efficiently Counteracts the Inflammation-Induced Changes of the Iron Homeostasis System in Macrophages [J].
Cutone, Antimo ;
Rosa, Luigi ;
Lepanto, Maria Stefania ;
Scotti, Mellani Jinnett ;
Berlutti, Francesca ;
di Patti, Maria Carmela Bonaccorsi ;
Musci, Giovanni ;
Valenti, Piera .
FRONTIERS IN IMMUNOLOGY, 2017, 8
[5]   The investigation and treatment of secondary anaemia [J].
Davis, Sarah L. ;
Littlewood, T. J. .
BLOOD REVIEWS, 2012, 26 (02) :65-71
[6]   Metabolic Reprogramming of Macrophages GLUCOSE TRANSPORTER 1 (GLUT1)-MEDIATED GLUCOSE METABOLISM DRIVES A PROINFLAMMATORY PHENOTYPE [J].
Freemerman, Alex J. ;
Johnson, Amy R. ;
Sacks, Gina N. ;
Milner, J. Justin ;
Kirk, Erin L. ;
Troester, Melissa A. ;
Macintyre, Andrew N. ;
Goraksha-Hicks, Pankuri ;
Rathmell, Jeffery C. ;
Makowski, Liza .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (11) :7884-7896
[7]   Fc- and complement-receptor activation stimulates cell cycle progression of macrophage cells from G1 to S1 [J].
Luo, Y ;
Tucker, SC ;
Casadevall, A .
JOURNAL OF IMMUNOLOGY, 2005, 174 (11) :7226-7233
[8]   The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study [J].
Maccio, Antonio ;
Madeddu, Clelia ;
Gramignano, Giulia ;
Mulas, Carlo ;
Tanca, Luciana ;
Cherchi, Maria Cristina ;
Floris, Carlo ;
Omoto, Itaru ;
Barracca, Antonio ;
Ganz, Tomas .
HAEMATOLOGICA, 2015, 100 (01) :124-132
[9]   Efficacy and Safety of Oral Lactoferrin Supplementation in Combination with rHuEPO-β for the Treatment of Anemia in Advanced Cancer Patients Undergoing Chemotherapy: Open-Label, Randomized Controlled Study [J].
Maccio, Antonio ;
Madeddu, Clelia ;
Gramignano, Giulia ;
Mulas, Carlo ;
Sanna, Eleonora ;
Mantovani, Giovanni .
ONCOLOGIST, 2010, 15 (08) :894-902
[10]   Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines [J].
Murray, Peter J. ;
Allen, Judith E. ;
Biswas, Subhra K. ;
Fisher, Edward A. ;
Gilroy, Derek W. ;
Goerdt, Sergij ;
Gordon, Siamon ;
Hamilton, John A. ;
Ivashkiv, Lionel B. ;
Lawrence, Toby ;
Locati, Massimo ;
Mantovani, Alberto ;
Martinez, Fernando O. ;
Mege, Jean-Louis ;
Mosser, David M. ;
Natoli, Gioacchino ;
Saeij, Jeroen P. ;
Schultze, Joachim L. ;
Shirey, Kari Ann ;
Sica, Antonio ;
Suttles, Jill ;
Udalova, Irina ;
van Ginderachter, Jo A. ;
Vogel, Stefanie N. ;
Wynn, Thomas A. .
IMMUNITY, 2014, 41 (01) :14-20