One-pot, four-component synthesis of spiroindoloquinazoline derivatives as phospholipase inhibitors

被引：25

作者：

Beyrati, Maryam ^{[1
]}

Forutan, Maryam ^{[1
]}

Hasaninejad, Alireza ^{[1
]}

Rakovsky, Erik ^{[2
]}

Babaei, Somayyeh ^{[1
]}

Maryamabadi, Ammar ^{[1
]}

Mohebbi, Gholamhossein ^{[3
]}

机构：

[1] Persian Gulf Univ, Dept Chem, Fac Sci, Bushehr 75169, Iran

[2] Comenius Univ, Dept Inorgan Chem, Fac Nat Sci, Ilkovicova 6, Bratislava 84215, Slovakia

[3] Bushehr Univ Med Sci, Persian Gulf Marine Biotechnol Res Ctr, Persian Gulf Biomed Res Ctr, Bushehr, Iran

来源：

TETRAHEDRON | 2017年 / 73卷 / 34期

关键词：

One-pot synthesis; Spiroindoloquinazoline; DABCO; Phospholipase inhibitors; Molecular docking; VITRO ANTITUMOR-ACTIVITY; 3-COMPONENT SYNTHESIS; HIGHLY EFFICIENT; TRYPTANTHRIN; CATALYST; SPIRO;

D O I：

10.1016/j.tet.2017.07.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, one-pot, two-step, four-component reaction for the synthesis of spiroindoloquinazoline derivatives in the presence of 1,4-diazabicyclo[2.2.21]octane (DABCO) is described. The syntheses are achieved by the condensation reaction of isatin derivatives, isatoic anhydride, malononitrile and carbonyl compounds under refiux in acetonitrile. Several of the resulting compounds showed moderate activity as phospholipase A2 inhibitors. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：5144 / 5152

页数：9

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