Cancer biology as revealed by the research autopsy

被引：62

作者：

Iacobuzio-Donahue, Christine A. ^{[1
,2
,3
]}

Michael, Chelsea ^{[4
]}

Baez, Priscilla ^{[1
]}

Kappagantula, Rajya ^{[1
]}

Hooper, Jody E. ^{[5
]}

Hollman, Travis J. ^{[1
,6
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, David M Rubenstein Ctr Pancreat Canc Res, 1275 York Ave, New York, NY 10021 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Hlth Informat, 1275 York Ave, New York, NY 10021 USA

[5] Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA

[6] Mem Sloan Kettering Canc Ctr, Parker Inst Canc Immunotherapy, 1275 York Ave, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2019年 / 19卷 / 12期

基金：

美国国家卫生研究院;

关键词：

PANCREATIC-CANCER; GENE-EXPRESSION; POSTMORTEM INTERVAL; MESSENGER-RNA; RAPID AUTOPSY; BRAIN-DEATH; METASTASIS; HETEROGENEITY; EVOLUTION; CELL;

D O I：

10.1038/s41568-019-0199-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A research autopsy is a post-mortem medical procedure performed on a deceased individual with the primary goal of collecting tissue to support basic and translational research. This approach has increasingly been used to investigate the pathophysiological mechanisms of cancer evolution, metastasis and treatment resistance. In this Review, we discuss the rationale for the use of research autopsies in cancer research and provide an evidence-based discussion of the quality of post-mortem tissues compared with other types of biospecimens. We also discuss the advantages of using post-mortem tissues over other types of biospecimens, including the large amounts of tissue that can be obtained and the extent of multiregion sampling that is achievable, which is not otherwise possible in living patients. We highlight how the research autopsy has supported the identification of the clonal origins and modes of spread among metastases, the extent that selective pressures imposed by treatments cause bottlenecks leading to parallel and convergent tumour evolution, and the creation of rare tissue banks and patient-derived model systems. Finally, we comment on the future of the research autopsy as an integral component of precision medicine strategies.

引用

页码：686 / 697

页数：12

共 152 条

[71] Single-Cell Transcriptomic Analysis of Tumor Heterogeneity [J].

Levitin, Hanna Mendes ;

Yuan, Jinzhou ;

Sims, Peter A. .

TRENDS IN CANCER, 2018, 4 (04) :264-268

[72] Sample matching by inferred agonal stress in gene expression analyses of the brain [J].

Li, Jun Z. ;

Meng, Fan ;

Tsavaler, Larisa ;

Evans, Simon J. ;

Choudary, Prabhakara V. ;

Tomita, Hiroaki ;

Vawter, Marquis P. ;

Walsh, David ;

Shokoohi, Vida ;

Chung, Tisha ;

Bunney, William E. ;

Jones, Edward G. ;

Akil, Huda ;

Watson, Stanley J. ;

Myers, Richard M. .

BMC GENOMICS, 2007, 8 (1)

[73] Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer [J].

Liu, Wennuan ;

Laitinen, Sari ;

Khan, Sofia ;

Vihinen, Mauno ;

Kowalski, Jeanne ;

Yu, Guoqiang ;

Chen, Li ;

Ewing, Charles M. ;

Eisenberger, Mario A. ;

Carducci, Michael A. ;

Nelson, William G. ;

Yegnasubramanian, Srinivasan ;

Luo, Jun ;

Wang, Yue ;

Xu, Jianfeng ;

Isaacs, William B. ;

Visakorpi, Tapio ;

Bova, Steven .

NATURE MEDICINE, 2009, 15 (05) :559-565

[74] The Genotype-Tissue Expression (GTEx) project [J].

Lonsdale, John ;

Thomas, Jeffrey ;

Salvatore, Mike ;

Phillips, Rebecca ;

Lo, Edmund ;

Shad, Saboor ;

Hasz, Richard ;

Walters, Gary ;

Garcia, Fernando ;

Young, Nancy ;

Foster, Barbara ;

Moser, Mike ;

Karasik, Ellen ;

Gillard, Bryan ;

Ramsey, Kimberley ;

Sullivan, Susan ;

Bridge, Jason ;

Magazine, Harold ;

Syron, John ;

Fleming, Johnelle ;

Siminoff, Laura ;

Traino, Heather ;

Mosavel, Maghboeba ;

Barker, Laura ;

Jewell, Scott ;

Rohrer, Dan ;

Maxim, Dan ;

Filkins, Dana ;

Harbach, Philip ;

Cortadillo, Eddie ;

Berghuis, Bree ;

Turner, Lisa ;

Hudson, Eric ;

Feenstra, Kristin ;

Sobin, Leslie ;

Robb, James ;

Branton, Phillip ;

Korzeniewski, Greg ;

Shive, Charles ;

Tabor, David ;

Qi, Liqun ;

Groch, Kevin ;

Nampally, Sreenath ;

Buia, Steve ;

Zimmerman, Angela ;

Smith, Anna ;

Burges, Robin ;

Robinson, Karna ;

Valentino, Kim ;

Bradbury, Deborah .

NATURE GENETICS, 2013, 45 (06) :580-585

[75] FunSPU: A versatile and adaptive multiple functional annotation-based association test of whole-genome sequencing data [J].

Ma, Yiding ;

Wei, Peng .

PLOS GENETICS, 2019, 15 (04)

[76] Precancerous neoplastic cells can move through the pancreatic ductal system [J].

Makohon-Moore, Alvin P. ;

Matsukuma, Karen ;

Zhang, Ming ;

Reiter, Johannes G. ;

Gerold, Jeffrey M. ;

Jiao, Yuchen ;

Sikkema, Lisa ;

Attiyeh, Marc A. ;

Yachida, Shinichi ;

Sandone, Corinne ;

Hruban, Ralph H. ;

Klimstra, David S. ;

Papadopoulos, Nickolas ;

Nowak, Martin A. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Iacobuzio-Donahue, Christine A. .

NATURE, 2018, 561 (7722) :201-+

[77] Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer [J].

Makohon-Moore, Alvin P. ;

Zhang, Ming ;

Reiter, Johannes G. ;

Bozic, Ivana ;

Allen, Benjamin ;

Kundu, Deepanjan ;

Chatterjee, Krishnendu ;

Wong, Fay ;

Jiao, Yuchen ;

Kohutek, Zachary A. ;

Hong, Jungeui ;

Attiyeh, Marc ;

Javier, Breanna ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Nowak, Martin A. ;

Papadopoulos, Nickolas ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Iacobuzio-Donahue, Christine A. .

NATURE GENETICS, 2017, 49 (03) :358-366

[78] Classifying the evolutionary and ecological features of neoplasms [J].

Maley, Carlo C. ;

Aktipis, Athena ;

Graham, Trevor A. ;

Sottoriva, Andrea ;

Boddy, Amy M. ;

Janiszewska, Michalina ;

Silva, Ariosto S. ;

Gerlinger, Marco ;

Yuan, Yinyin ;

Pienta, Kenneth J. ;

Anderson, Karen S. ;

Gatenby, Robert ;

Swanton, Charles ;

Posada, David ;

Wu, Chung-I ;

Schiffman, Joshua D. ;

Hwang, E. Shelley ;

Polyak, Kornelia ;

Anderson, Alexander R. A. ;

Brown, Joel S. ;

Greaves, Mel ;

Shibata, Darryl .

NATURE REVIEWS CANCER, 2017, 17 (10) :605-619

[79] Clonality inference in multiple tumor samples using phylogeny [J].

Malikic, Salem ;

McPherson, Andrew W. ;

Donmez, Nilgun ;

Sahinalp, Cenk S. .

BIOINFORMATICS, 2015, 31 (09) :1349-1356

[80] Tumor Dormancy and Relapse: From a Natural Byproduct of Evolution to a Disease State [J].

Manjili, Masoud H. .

CANCER RESEARCH, 2017, 77 (10) :2564-2569

← 3 4 5 6 7 8 9 10 11 12 →