Cancer biology as revealed by the research autopsy

被引：62

作者：

Iacobuzio-Donahue, Christine A. ^{[1
,2
,3
]}

Michael, Chelsea ^{[4
]}

Baez, Priscilla ^{[1
]}

Kappagantula, Rajya ^{[1
]}

Hooper, Jody E. ^{[5
]}

Hollman, Travis J. ^{[1
,6
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, David M Rubenstein Ctr Pancreat Canc Res, 1275 York Ave, New York, NY 10021 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Hlth Informat, 1275 York Ave, New York, NY 10021 USA

[5] Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA

[6] Mem Sloan Kettering Canc Ctr, Parker Inst Canc Immunotherapy, 1275 York Ave, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2019年 / 19卷 / 12期

基金：

美国国家卫生研究院;

关键词：

PANCREATIC-CANCER; GENE-EXPRESSION; POSTMORTEM INTERVAL; MESSENGER-RNA; RAPID AUTOPSY; BRAIN-DEATH; METASTASIS; HETEROGENEITY; EVOLUTION; CELL;

D O I：

10.1038/s41568-019-0199-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A research autopsy is a post-mortem medical procedure performed on a deceased individual with the primary goal of collecting tissue to support basic and translational research. This approach has increasingly been used to investigate the pathophysiological mechanisms of cancer evolution, metastasis and treatment resistance. In this Review, we discuss the rationale for the use of research autopsies in cancer research and provide an evidence-based discussion of the quality of post-mortem tissues compared with other types of biospecimens. We also discuss the advantages of using post-mortem tissues over other types of biospecimens, including the large amounts of tissue that can be obtained and the extent of multiregion sampling that is achievable, which is not otherwise possible in living patients. We highlight how the research autopsy has supported the identification of the clonal origins and modes of spread among metastases, the extent that selective pressures imposed by treatments cause bottlenecks leading to parallel and convergent tumour evolution, and the creation of rare tissue banks and patient-derived model systems. Finally, we comment on the future of the research autopsy as an integral component of precision medicine strategies.

引用

页码：686 / 697

页数：12

共 152 条

[1] Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution [J].

Abbosh, Christopher ;

Birkbak, Nicolai J. ;

Wilson, Gareth A. ;

Jamal-Hanjani, Mariam ;

Constantin, Tudor ;

Salari, Raheleh ;

Le Quesne, John ;

Moore, David A. ;

Veeriah, Selvaraju ;

Rosenthal, Rachel ;

Marafioti, Teresa ;

Kirkizlar, Eser ;

Watkins, Thomas B. K. ;

McGranahan, Nicholas ;

Ward, Sophia ;

Martinson, Luke ;

Riley, Joan ;

Fraioli, Francesco ;

Al Bakir, Maise ;

Gronroos, Eva ;

Zambrana, Francisco ;

Endozo, Raymondo ;

Bi, Wenya Linda ;

Fennessy, Fiona M. ;

Sponer, Nicole ;

Johnson, Diana ;

Laycock, Joanne ;

Shafi, Seema ;

Czyzewska-Khan, Justyna ;

Rowan, Andrew ;

Chambers, Tim ;

Matthews, Nik ;

Turajlic, Samra ;

Hiley, Crispin ;

Lee, Siow Ming ;

Forster, Martin D. ;

Ahmad, Tanya ;

Falzon, Mary ;

Borg, Elaine ;

Lawrence, David ;

Hayward, Martin ;

Kolvekar, Shyam ;

Panagiotopoulos, Nikolaos ;

Janes, Sam M. ;

Thakrar, Ricky ;

Ahmed, Asia ;

Blackhall, Fiona ;

Summers, Yvonne ;

Hafez, Dina ;

Naik, Ashwini .

NATURE, 2017, 545 (7655) :446-+

[2] Metastatic breast cancer patients: attitudes toward tissue donation for rapid autopsy [J].

Achkar, Tala ;

Wilson, John ;

Simon, Jacqueline ;

Rosenzweig, Margaret ;

Puhalla, Shannon .

BREAST CANCER RESEARCH AND TREATMENT, 2016, 155 (01) :159-164

[3] Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine [J].

Aguirre, Andrew J. ;

Nowak, Jonathan A. ;

Camarda, Nicholas D. ;

Moffitt, Richard A. ;

Ghazani, Arezou A. ;

Hazar-Rethinam, Mehlika ;

Raghavan, Srivatsan ;

Kim, Jaegil ;

Brais, Lauren K. ;

Ragon, Dorisanne ;

Welch, Marisa W. ;

Reilly, Emma ;

McCabe, Devin ;

Marini, Lori ;

Anderka, Kristin ;

Helvie, Karla ;

Oliver, Nelly ;

Babic, Ana ;

Da Silva, Annacarolina ;

Nadres, Brandon ;

Van Seventer, Emily E. ;

Shahzade, Heather A. ;

St Pierre, Joseph P. ;

Burke, Kelly P. ;

Clancy, Thomas ;

Cleary, James M. ;

Doyle, Leona A. ;

Jajoo, Kunal ;

McCleary, Nadine J. ;

Meyerhardt, Jeffrey A. ;

Murphy, Janet E. ;

Ng, Kimmie ;

Patel, Anuj K. ;

Perez, Kimberly ;

Rosenthal, Michael H. ;

Rubinson, Douglas A. ;

Ryou, Marvin ;

Shapiro, Geoffrey I. ;

Sicinska, Ewa ;

Silverman, Stuart G. ;

Nagy, Rebecca J. ;

Lanman, Richard B. ;

Knoerzer, Deborah ;

Welsch, Dean J. ;

Yurgelun, Matthew B. ;

Fuchs, Charles S. ;

Garraway, Levi A. ;

Getz, Gad ;

Hornick, Jason L. ;

Johnson, Bruce E. .

CANCER DISCOVERY, 2018, 8 (09) :1096-1111

[4] Overcoming autopsy barriers in pediatric cancer research [J].

Alabran, Jennifer L. ;

Hooper, Jody E. ;

Hill, Melissa ;

Smith, Sandra E. ;

Spady, Kimberlee K. ;

Davis, Lara E. ;

Peterson, Lauren S. ;

Malempati, Suman ;

Ryan, Christopher W. ;

Acosta, Rae ;

Spunt, Sheri L. ;

Keller, Charles .

PEDIATRIC BLOOD & CANCER, 2013, 60 (02) :204-209

[5] A community-based model of rapid autopsy in end-stage cancer patients [J].

Alsop, Kathryn ;

Thorne, Heather ;

Sandhu, Shahneen ;

Hamilton, Anne ;

Mintoff, Christopher ;

Christie, Elizabeth ;

Spruyt, Odette ;

Williams, Scott ;

McNally, Orla ;

Mileshkin, Linda ;

Ananda, Sumitra ;

Hallo, Julene ;

Loi, Sherene ;

Scott, Clare ;

Savas, Peter ;

Devereux, Lisa ;

O'Brien, Patricia ;

Gunawardena, Sameera ;

Hampson, Clare ;

Strachan, Kate ;

Jaravaza, Rufaro Diana ;

Francis, Victoria ;

Young, Gregory ;

Ranson, David ;

Samaranayake, Ravindra ;

Stevens, David ;

Boyle, Samantha ;

Fedele, Clare ;

Topp, Monique ;

Ho, Gwo ;

Teo, Zhi Ling ;

Taylor, Renea A. ;

Papargiris, Melissa M. ;

Lawrencelz, Mitchell G. ;

Wang, Hong ;

Risbridger, Gail P. ;

Haynes, Nicole M. ;

Medon, Mikolaj ;

Johnstone, Ricky W. ;

Vidacs, Eva ;

Arnau, Gisela Mir ;

Vergara, Ismael A. ;

Papenfuss, Anthony T. ;

McArthur, Grant ;

Waring, Paul ;

Carvosso, Shirley ;

Angel, Christopher ;

Gyorki, David ;

Solomon, Benjamin ;

Mitchell, Gillian .

NATURE BIOTECHNOLOGY, 2016, 34 (10) :1010-1014

[6] DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases [J].

Aryee, Martin J. ;

Liu, Wennuan ;

Engelmann, Julia C. ;

Nuhn, Philipp ;

Gurel, Meltem ;

Haffner, Michael C. ;

Esopi, David ;

Irizarry, Rafael A. ;

Getzenberg, Robert H. ;

Nelson, William G. ;

Luo, Jun ;

Xu, Jianfeng ;

Isaacs, William B. ;

Bova, G. Steven ;

Yegnasubramanian, Srinivasan .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (169)

[7] Transcriptional Mechanisms of Resistance to Anti-PD-1 Therapy [J].

Ascierto, Maria L. ;

Makohon-Moore, Alvin ;

Lipson, Evan J. ;

Taube, Janis M. ;

McMiller, Tracee L. ;

Berger, Alan E. ;

Fan, Jinshui ;

Kaunitz, Genevieve J. ;

Cottrell, Tricia R. ;

Kohutek, Zachary A. ;

Favorov, Alexander ;

Makarov, Vladimir ;

Riaz, Nadeem ;

Chan, Timothy A. ;

Cope, Leslie ;

Hruban, Ralph H. ;

Pardoll, Drew M. ;

Taylor, Barry S. ;

Solit, David B. ;

Iacobuzio-Donahue, Christine A. ;

Topalian, Suzanne L. .

CLINICAL CANCER RESEARCH, 2017, 23 (12) :3168-3180

[8] POSTMORTEM STABILITY OF DNA [J].

BAR, W ;

KRATZER, A ;

MACHLER, M ;

SCHMID, W .

FORENSIC SCIENCE INTERNATIONAL, 1988, 39 (01) :59-70

[9] FACTORS DETERMINING THE TIME COURSE OF RIGOR MORTIS [J].

BATESMITH, EC ;

BENDALL, JR .

JOURNAL OF PHYSIOLOGY-LONDON, 1949, 110 (1-2) :47-65

[10] RNA in forensic science [J].

Bauer, M. .

FORENSIC SCIENCE INTERNATIONAL-GENETICS, 2007, 1 (01) :69-74

← 1 2 3 4 5 6 7 8 9 10 →