Burkitt Leukemia With Precursor B-Cell Immunophenotype and Dual Translocation of t(14;18) and t(8;14) in a Child: Case Report and Review of the Literature

被引：0

作者：

Odaman, Al Isik ^{[1
]}

Bayram, Cengiz ^{[1
]}

Koc, Basak ^{[1
]}

Ersoy, Gizem ^{[1
]}

Uysalol, Ezgi Pasli ^{[1
]}

Aki, Hilal ^{[2
]}

Ozdemir, Gul Nihal ^{[1
]}

机构：

[1] Kanuni Sultan Suleyman Educ & Res Hosp, Dept Pediat Hematol & Oncol, TR-34303 Istanbul, Turkey

[2] Istanbul Univ, Cerrahpasa Fac Med, Dept Pathol, Istanbul, Turkey

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2020年 / 42卷 / 01期

关键词：

Burkitt leukemia; immunophenotype; t(8; 14); ACUTE LYMPHOBLASTIC-LEUKEMIA; MYC; MORPHOLOGY; LEUKEMIA/LYMPHOMA; T(14-18); COMMON; LOCUS; BCL2;

D O I：

10.1097/MPH.0000000000001354

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Burkitt leukemia (BL) with the precursor B-cell immunophenotype is a rarely reported condition. The prognosis of such patients is similar to that of classic BL. However, the combination of chromosomal translocations associated with bcl-2 and c-myc rearrangement has a poor prognosis. Observations: An 11-year-old child presented with fever and weakness. Bone marrow aspiration showed morphologically L1 type blasts and flow cytometry analysis was compatible with precursor B-cell immunophenotype. Cytogenetic analysis revealed a combination of t(8;14) and t(14;l8). Conclusions: The combination of t(8;14) and t(14;l8) can exhibit different immunophenotypical and morphologic features in leukemias.

引用

页码：E61 / E63

页数：3