Ru-catalyzed asymmetric hydrogenation of α-phthalimide ketones and 1,3-diaryl diketones using 4,4′-substituted BINAPs

被引：34

作者：

Hu, AG ^{[1
]}

Lin, WB ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 03期

关键词：

D O I：

10.1021/ol0474812

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A family of tunable precatalysts [NH2Et2][{Ru(4,4'-BINAP)Cl}(2)(mu-Cl)(3)] was synthesized and used for highly enantioselective hydrogenation of phthalimide-protected amino ketones and 1,3-diaryldiketones. The bulky groups on the 4,4'-positions of BINAP were believed to be responsible for the enhancement of enantioselectivity (and diasteroselectivity) in these reactions.

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页码：455 / 458

页数：4

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