Francisella tularensis as a potential agent of bioterrorism?

被引：48
作者：
Maurin, Max [1 ,2 ,3 ]
机构：
[1] CHU Grenoble, Ctr Natl Reference Francisella, Dept Agents Infect, Inst Biol & Pathol, F-38043 Grenoble, France
[2] Univ Grenoble Alpes, LAPM, F-38000 Grenoble, France
[3] CNRS, LAPM, UMR 5163, F-38000 Grenoble, France
来源：
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2015年 / 13卷 / 02期
关键词：
biological threat; bioterrorism; category A bioterrorism agents; drug development; Francisella tularensis; new drugs; tularemia; TULAREMIA; IDENTIFICATION; CIPROFLOXACIN; RESISTANCE; DIAGNOSIS; THERAPY;
D O I：
10.1586/14787210.2015.986463
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Francisella tularensis is a category A bioterrorism agent. It is the etiological agent of tularemia, a zoonotic disease found throughout the northern hemisphere. The intentional spread of F. tularensis aerosols would probably lead to severe and often fatal pneumonia cases, but also secondary cases from contaminated animals and environments. We are not ready to face such a situation. No vaccine is currently available. A few antibiotics are active against F. tularensis, but strains resistant to these antibiotics could be used in the context of bioterrorism. We need new therapeutic strategies to fight against category A bioterrorism agents, including development of new drugs inhibiting F. tularensis growth and/or virulence, or enhancing the host response to infection by this pathogen. © 2015 Informa UK, Ltd.
引用
收藏
页码：141 / 144
页数：4
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