STAMPing at the crossroads of normal physiology and disease states

被引:20
作者
Sikkeland, Jorgen [1 ]
Sheng, Xia [1 ]
Jin, Yang [1 ]
Saatcioglu, Fahri [1 ,2 ]
机构
[1] Univ Oslo, Dept Biosci, Oslo, Norway
[2] Oslo Univ Hosp, Inst Canc Genet & Informat, Oslo, Norway
关键词
STAMP; STEAP; Ironreductase; Prostate cancer; Metabolism; Inflammation; TUMOR-NECROSIS-FACTOR; 6-TRANSMEMBRANE EPITHELIAL ANTIGEN; ADIPOSE-RELATED PROTEIN; GENE-EXPRESSION SIGNATURE; 6 TRANSMEMBRANE PROTEIN; ALPHA-INDUCED PROTEIN; PROSTATE; STEAP4; NF-KAPPA-B; METABOLIC SYNDROME; POSITIVE REGULATOR;
D O I
10.1016/j.mce.2016.02.013
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The six transmembrane protein of prostate (STAMP) proteins, also known as six transmembrane epithelial antigen of prostate (STEAPs), comprises three members: STAMP1-3. Their expression is regulated by a variety of stimuli, including hormones and cytokines, in varied settings and tissues with important roles in secretion and cell differentiation. In addition, they are implicated in metabolic and inflammatory diseases and cancer. Here, we review the current knowledge on the role of STAMPs in both physiological and pathological states. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:26 / 36
页数:11
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