Enhanced expression of interleukin-6 in bone and serum of metastatic renal cell carcinoma

被引：18
作者：
Paule, B
Clerc, D
Rudant, C
Coulombel, C
Bonhomme-Faivre, L
Quillard, J
Bisson, M
机构：
[1] Hop Bicetre, Serv Rhumatol, F-94275 Le Kremlin Bicetre, France
[2] Univ Paris 05, UFR Biomed, UPR 37, F-75270 Paris, France
[3] Hop Paul Brousse, Dept Pharmacol, Serv Pharm, Villejuif, France
[4] Hop Bicetre, Serv Anatomopathol, F-94275 Le Kremlin Bicetre, France
来源：
HUMAN PATHOLOGY | 1998年 / 29卷 / 04期
关键词：
interleukin-6; bone metastasis; renal cell carcinoma; immunohistochemistry;
D O I：
10.1016/S0046-8177(98)90128-9
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Interleukin-6 (IL-6) is produced by renal cell carcinoma (RCC) cell lines and primary tumors. Using immunohistochemical staining in two RCC patients with hypercalcemia and high serum levels of free and total IL-6, we showed expression of IL-6 in metastatic bone tissue. The role of IL-6 in hypercalcemia and bone resorption would suggest that bisphosphonates or dexamethasone could be useful as adjuvant therapy for IL-6 dependant bone metastases which fail to respond to interferon alpha (IFN) alpha 2a and all trans retinoic acid (ATRA). Copyright (C) 1998 by W.B. Saunders Company.
引用
收藏
页码：421 / 424
页数：4
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