A Complete Optical Sensor System Based on a POF-SPR Platform and a Thermo-Stabilized Flow Cell for Biochemical Applications

被引：27

作者：

Cennamo, Nunzio ^{[1
]}

Chiavaioli, Francesco ^{[2
]}

Trono, Cosimo ^{[2
]}

Tombelli, Sara ^{[2
]}

Giannetti, Ambra ^{[2
]}

Baldini, Francesco ^{[2
]}

Zeni, Luigi ^{[1
]}

机构：

[1] Univ Naples 2, Dept Ind & Informat Engn, Via Roma 29, I-81031 Aversa, Italy

[2] CNR, Inst Appl Phys Nello Carrara, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy

来源：

SENSORS | 2016年 / 16卷 / 02期

关键词：

plastic optical fiber; surface plasmon resonance; flow cell; biosensors; sensors system; SURFACE-PLASMON RESONANCE; FIBER SENSOR; BIOSENSOR; GOLD; REGENERATION; SENSITIVITY; PERFORMANCE; REMOVAL; MIP;

D O I：

10.3390/s16020196

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An optical sensor platform based on surface plasmon resonance (SPR) in a plastic optical fiber (POF) integrated into a thermo-stabilized flow cell for biochemical sensing applications is proposed. This device has been realized and experimentally tested by using a classic receptor-analyte assay. For this purpose, the gold surface of the POF was chemically modified through the formation of a self-assembling monolayer. The surface robustness of the POF-SPR platform has been tested for the first time thanks to the flow cell. The experimental results show that the proposed device can be successfully used for label-free biochemical sensing. The final goal of this work is to achieve a complete, small-size, simple to use and low cost optical sensor system. The whole system with the flow cell and the optical sensor are extensively described, together with the experimental results obtained with an immunoglobulin G (IgG)/anti-IgG assay.

引用

页数：9

共 30 条

[1]

[Anonymous], 2009, J SENS

[2] Smart design of fiber optic surfaces for improved plasmonic biosensing [J].

Arghir, Iulia ;

Delport, Filip ;

Spasic, Dragana ;

Lammertyn, Jeroen .

NEW BIOTECHNOLOGY, 2015, 32 (05) :473-484

[3] Improved surface plasmon resonance biosensing using silanized optical fibers [J].

Arghir, Iulia ;

Spasic, Dragana ;

Verlinden, Bert E. ;

Delport, Filip ;

Lammertyn, Jeroen .

SENSORS AND ACTUATORS B-CHEMICAL, 2015, 216 :518-526

[4] Formation and removal of alkylthiolate self-assembled monolayers on gold in aqueous solutions [J].

Canaria, CA ;

So, J ;

Maloney, JR ;

Yu, CJ ;

Smith, JO ;

Roukes, ML ;

Fraser, SE ;

Lansford, R .

LAB ON A CHIP, 2006, 6 (02) :289-295

[5] High selectivity and sensitivity sensor based on MIP and SPR in tapered plastic optical fibers for the detection of L-nicotine [J].

Cennamo, N. ;

D'Agostino, G. ;

Pesavento, M. ;

Zeni, L. .

SENSORS AND ACTUATORS B-CHEMICAL, 2014, 191 :529-536

[6] An easy way to realize SPR aptasensor: A multimode plastic optical fiber platform for cancer biomarkers detection [J].

Cennamo, Nunzio ;

Pesavento, Maria ;

Lunelli, Lorenzo ;

Vanzetti, Lia ;

Pederzolli, Cecilia ;

Zeni, Luigi ;

Pasquardini, Laura .

TALANTA, 2015, 140 :88-95

[7] Monitoring of Low Levels of Furfural in Power Transformer Oil with a Sensor System Based on a POF-MIP Platform [J].

Cennamo, Nunzio ;

De Maria, Letizia ;

D'Agostino, Girolamo ;

Zeni, Luigi ;

Pesavento, Maria .

SENSORS, 2015, 15 (04) :8499-8511

[8] An innovative plastic optical fiber-based biosensor for new bio/applications. The case of celiac disease [J].

Cennamo, Nunzio ;

Varriale, Antonio ;

Pennacchio, Anna ;

Staiano, Maria ;

Massarotti, Davide ;

Zeni, Luigi ;

D'Auria, Sabato .

SENSORS AND ACTUATORS B-CHEMICAL, 2013, 176 :1008-1014

[9] Performance Comparison of Two Sensors Based on Surface Plasmon Resonance in a Plastic Optical Fiber [J].

Cennamo, Nunzio ;

Massarotti, Davide ;

Galatus, Ramona ;

Conte, Laura ;

Zeni, Luigi .

SENSORS, 2013, 13 (01) :721-735

[10] Low Cost Sensors Based on SPR in a Plastic Optical Fiber for Biosensor Implementation [J].

Cennamo, Nunzio ;

Massarotti, Davide ;

Conte, Laura ;

Zeni, Luigi .

SENSORS, 2011, 11 (12) :11752-11760

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