Biological Rationale for the Intramedullary Canal as a Source of Autograft Material

被引：20

作者：

Hak, David J. ^{[1
]}

Pittman, Jason L. ^{[2
]}

机构：

[1] Denver Hlth Univ Colorado, Dept Orthoped Surg, Denver, CO 80204 USA

[2] Boston Univ, Sch Med, Dept Orthoped Surg, Boston, MA 02118 USA

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 2010年 / 41卷 / 01期

关键词：

Autogenous bone graft; Intramedullary bone graft harvest; Reamer irrigator aspirator; Growth factors; Bone formation; VERTEBRAL BODY; REAMING DEBRIS; BONE REAMINGS; CORTICAL HEAT; TEMPERATURE; ASPIRATE; CELLS; GRAFT;

D O I：

10.1016/j.ocl.2009.07.005

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Bone harvested by intramedullary reaming offers a minimally invasive alternative to harvesting bone from the iliac crest, which has long been considered the gold standard for autogenous bone grafting. The biologic potential of intramedullary reaming material has been studied both in vitro and in vivo. The material provides osteogenic, osteoinductive, and osteoconductive properties that are comparable to the material harvested from the iliac crest. In addition to the ability to obtain a large volume of bone, the graft harvested by the Reamer-Irrigator-Aspirator has been shown to be rich in growth factors, including BMP-2, TGF-beta 1, IGF-I, FGFa, and PDGFbb.

引用

页码：57 / +

页数：6

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