Reactions of cyclic enhydrazinoketones with arylidene derivatives of malononitrile.: Synthesis of fused N-substituted 1,4-dihydropyridines

被引：12

作者：

Lichitsky, BV ^{[1
]}

Yarovenko, VN ^{[1
]}

Zavarzin, IV ^{[1
]}

Krayushkin, MM ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 117913, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2000年 / 49卷 / 07期

关键词：

cyclic enhydrazinoketones; arylidenemalononitriles; fused 1,4-dihydropyridines; Michael reaction;

D O I：

10.1007/BF02495769

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for the synthesis of fused N-amino-1,4-dihydropyridines was proposed. The method is based on the addition of cyclic enhydrazinoketones to arylidenemalononitriles. The structures of the compounds synthesized were studied using H-1 NMR spectroscopy.

引用

页码：1251 / 1254

页数：4

共 7 条

[1]

DOMNIN NA, 1957, ZH OBSHCH KHIM+, V27, P665

[2] REACTION OF CYCLOALKANE-1,3-DIONES WITH HYDRAZINES .1. [J].

EISTERT, B ;

KILPPER, G ;

GORING, J .

CHEMISCHE BERICHTE-RECUEIL, 1969, 102 (04) :1379-&

[3] 1,4-DIHYDROPYRIDINES - EFFECTS OF CHIRALITY AND CONFORMATION ON THE CALCIUM-ANTAGONIST AND CALCIUM AGONIST ACTIVITIES [J].

GOLDMANN, S ;

STOLTEFUSS, J .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (12) :1559-1578

[4]

HAMMOUDA M, 1994, PHARMAZIE, V49, P365

[5]

Holyoke Jr C. W., 1997, PCT Int. Appl., Patent No. [9711057, WO 9711057 A1 19970327]

[6]

1996, Patent No. 9528388

[7]

1996, Patent No. 5455253

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