IDEG6: a web tool for detection of differentially expressed genes in multiple tag sampling experiments

被引：316
作者：
Romualdi, C
Bortoluzzi, S
D'Alessi, F
Danieli, GA
机构：
[1] Univ Padua, CRIBI Biotechnol Ctr, I-35131 Padua, Italy
[2] Univ Padua, Dept Biol, I-35131 Padua, Italy
来源：
PHYSIOLOGICAL GENOMICS | 2003年 / 12卷 / 02期
关键词：
expressed sequence tags; serial analysis of gene expression; statistical test;
D O I：
10.1152/physiolgenomics.00096.2002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Here we present a novel web tool for the statistical analysis of gene expression data in multiple tag sampling experiments. Differentially expressed genes are detected by using six different test statistics. Result tables, linked to the GenBank, UniGene, or LocusLink database, can be browsed or searched in different ways. Software is freely available at the site: http:// telethon. bio. unipd. it/ bioinfo/ IDEG6_ form/, together with additional information on statistical methodologies.
引用
收藏
页码：159 / 162
页数：4
相关论文
共 11 条
[1]   The significance of digital gene expression profiles [J].
Audic, S ;
Claverie, JM .
GENOME RESEARCH, 1997, 7 (10) :986-995
[2]   Computational methods for the identification of differential and coordinated gene expression [J].
Claverie, JM .
HUMAN MOLECULAR GENETICS, 1999, 8 (10) :1821-1832
[3]   Gene Expression Omnibus: NCBI gene expression and hybridization array data repository [J].
Edgar, R ;
Domrachev, M ;
Lash, AE .
NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :207-210
[4]  
Greller LD, 1999, GENOME RES, V9, P282
[5]   LARGE-SCALE CDNA SEQUENCING FOR ANALYSIS OF QUANTITATIVE AND QUALITATIVE ASPECTS OF GENE-EXPRESSION [J].
OKUBO, K ;
HORI, N ;
MATOBA, R ;
NIIYAMA, T ;
FUKUSHIMA, A ;
KOJIMA, Y ;
MATSUBARA, K .
NATURE GENETICS, 1992, 2 (03) :173-179
[6]  
PHIMISTER B, 1999, NAT GENET, V21
[7]   Detecting differentially expressed genes in multiple tag sampling experiments: comparative evaluation of statistical tests [J].
Romualdi, C ;
Bortoluzzi, S ;
Danieli, GA .
HUMAN MOLECULAR GENETICS, 2001, 10 (19) :2133-2141
[8]   Pieces of the puzzle: expressed sequence tags and the catalog of human genes [J].
Schuler, GD .
JOURNAL OF MOLECULAR MEDICINE-JMM, 1997, 75 (10) :694-698
[9]   The comparison of gene expression from multiple cDNA libraries [J].
Stekel, DJ ;
Git, Y ;
Falciani, F .
GENOME RESEARCH, 2000, 10 (12) :2055-2061
[10]   SERIAL ANALYSIS OF GENE-EXPRESSION [J].
VELCULESCU, VE ;
ZHANG, L ;
VOGELSTEIN, B ;
KINZLER, KW .
SCIENCE, 1995, 270 (5235) :484-487
12