Treatment of Dry Age-Related Macular Degeneration

被引：37

作者：

Querques, Giuseppe ^{[1
,2
]}

Rosenfeld, Philip J. ^{[3
]}

Cavallero, Edoardo ^{[2
]}

Borrelli, Enrico ^{[2
]}

Corvi, Federico ^{[2
]}

Querques, Lea ^{[2
]}

Bandello, Francesco M. ^{[2
]}

Zarbin, Marco A. ^{[4
]}

机构：

[1] Univ Paris Est Creteil, Dept Ophthalmol, Ctr Hosp Intercommunal Creteil, Creteil, France

[2] Univ Sci Inst San Raffaele, Dept Ophthalmol, Milan, Italy

[3] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA

[4] Rutgers New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ USA

来源：

OPHTHALMIC RESEARCH | 2014年 / 52卷 / 03期

关键词：

Drusen; Geographic atrophy; Age-related macular degeneration; Treatment; Pathway; Drugs; Stem cells; Neurotrophic factors; Visual cycle; Oxidative damage; RETINAL-PIGMENT EPITHELIUM; CILIARY NEUROTROPHIC FACTOR; FACTOR-H POLYMORPHISM; CHOROIDAL BLOOD-FLOW; COMPLEMENT FACTOR-B; GEOGRAPHIC ATROPHY; DEHYDROGENASE-ACTIVITY; POTENTIAL THERAPY; BRUCHS MEMBRANE; OUTER SEGMENTS;

D O I：

10.1159/000363187

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A number of different approaches are under development for treating nonexudative manifestations of age-related macular degeneration (AMD). Some interventions target specific pathways that are believed to play a role in AMD pathogenesis, e.g. oxidative damage, lipofuscin accumulation, chronic inflammation (including complement activation), extracellular matrix changes (e.g. beta-amyloid accumulation), impaired choroidal blood flow, and apoptosis. In principle, these therapies can be combined ('combination therapy'), which may lead to synergistic effects that include better visual outcome, less likelihood for 'escape' (i.e. drug resistance), and less frequent treatment. (C) 2014 S. Karger AG, Basel

引用

页码：107 / 115

页数：9

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