The Emerging Importance of Liver Sinusoidal Endothelial Cells in Regulating Injury during Machine Perfusion of Deceased Liver Donors

被引：6
作者：
Bhogal, Ricky H. [1 ]
Mergental, Hynek [1 ]
Mirza, Darius F. [1 ]
Afford, Simon C. [1 ]
机构：
[1] Univ Birmingham, Coll Med & Dent Sci, Ctr Liver Res, Med Sch,Inst Biomed Res, Birmingham, W Midlands, England
来源：
SEMINARS IN LIVER DISEASE | 2018年 / 38卷 / 03期
关键词：
liver transplantation; liver sinusoidal endothelial cells; machine perfusion; donor liver; ischemia-reperfusion injury; HYPOTHERMIC OXYGENATED PERFUSION; COLD ISCHEMIC STORAGE; PORTAL-VEIN PERFUSION; REPERFUSION INJURY; NORMOTHERMIC PERFUSION; UNITED-STATES; TRANSPLANTATION; PRESERVATION; DONATION; MECHANISMS;
D O I：
10.1055/s-0038-1661371
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
While majority of liver transplants worldwide continue to be performed using deceased donor organs, the demands for donor livers continues to exceed the current supply. In an attempt to maximize the number of potentially usable donor livers and expand the current donor pool, there is intense global research by various groups exploring the role of machine perfusion in the liver transplantation, particularly with respect to the machine perfusion of extended-criteria liver donors. In this review, the authors summarize the current field of machine perfusion strategies as applied to deceased donor liver transplantation and how therapeutic targeting of the liver sinusoidal endothelial cell may improve the quality of donor livers.
引用
收藏
页码：252 / 259
页数：8
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