Prognostic value of HLA-DR expression and dendritic cell infiltration in gastric cancer

被引：59

作者：

Ishigami, S

Aikou, T

Natsugoe, S

Hokita, S

Iwashige, H

Tokushige, M

Sonoda, S

机构：

[1] Kagoshima Univ, Sch Med, Dept Surg 1, Kagoshima 892, Japan

[2] Kagoshima Univ, Sch Med, Dept Virol, Kagoshima 892, Japan

来源：

ONCOLOGY | 1998年 / 55卷 / 01期

关键词：

gastric cancer; HLA-DR; dendritic cells; immunodefense;

D O I：

10.1159/000011837

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We attempted to correlate the expression of human leukocyte antigen DR (HLA-DR) and tumor infiltration by S-100-protein-positive dendritic cells with clinicopathologic features in 165 patients with gastric cancer. The expression of HLA-DR was correlated with the histologic type, Infiltration of dendritic cells correlated negatively with distant lymph node metastases, clinical stage, and peritoneal invasion, There was no correlation between the expression of HLA-DR and infiltration by dendritic cells, In patients with resectable gastric cancer, the grade of infiltrating dendritic cells may be a suitable predictor of prognosis.

引用

页码：65 / 69

页数：5

共 22 条

[1]

BENACERRAF B, 1985, AM J PATHOL, V120, P334

[2] THE DETAILED DISTRIBUTION OF MHC CLASS-II ANTIGENS IN NORMAL HUMAN ORGANS [J].