The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate

被引：12

作者：

Ikbal, M ^{[1
]}

Tastekin, A

Dogan, H

Pirim, I

Ors, R

机构：

[1] Ataturk Univ, Fac Med, Dept Med Genet, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Fac Med, Div Neonatol, TR-25240 Erzurum, Turkey

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2004年 / 564卷 / 02期

关键词：

chloral hydrate; micronucleus; sister chromatid exchange; infants;

D O I：

10.1016/j.mrgentox.2004.08.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chloral hydrate is a sedative commonly used in pediatric medicine. It was evaluated for genotoxicity in cultured peripheral blood lymphocytes of infants who were given chloral hydrate for sedation. Sister chromatid exchange and micronucleus frequencies were determined before and after chloral hydrate administration. After treatment, the frequencies of sister chromatid exchange and micronuclei were significantly increased, suggesting that chloral hydrate has moderate genotoxic potential in infants. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：159 / 164

页数：6