The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate

被引：12

作者：

Ikbal, M ^{[1
]}

Tastekin, A

Dogan, H

Pirim, I

Ors, R

机构：

[1] Ataturk Univ, Fac Med, Dept Med Genet, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Fac Med, Div Neonatol, TR-25240 Erzurum, Turkey

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2004年 / 564卷 / 02期

关键词：

chloral hydrate; micronucleus; sister chromatid exchange; infants;

D O I：

10.1016/j.mrgentox.2004.08.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chloral hydrate is a sedative commonly used in pediatric medicine. It was evaluated for genotoxicity in cultured peripheral blood lymphocytes of infants who were given chloral hydrate for sedation. Sister chromatid exchange and micronucleus frequencies were determined before and after chloral hydrate administration. After treatment, the frequencies of sister chromatid exchange and micronuclei were significantly increased, suggesting that chloral hydrate has moderate genotoxic potential in infants. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：159 / 164

页数：6

共 41 条

[1] Aneuploidy: a report of an ECETOC task force [J].

Aardema, MJ ;

Albertini, S ;

Arni, P ;

Henderson, LM ;

Kirsch-Volders, M ;

Mackay, JM ;

Sarrif, AM ;

Stringer, DA ;

Taalman, RDF .

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 1998, 410 (01) :3-79

[2] SYNOPSIS OF THE INVIVO RESULTS OBTAINED WITH THE 10 KNOWN OR SUSPECTED ANEUGENS TESTED IN THE CEC COLLABORATIVE STUDY [J].

ADLER, ID .

MUTATION RESEARCH, 1993, 287 (01) :131-137

[3] MOUSE MICRONUCLEUS TESTS WITH KNOWN AND SUSPECT SPINDLE POISONS - RESULTS FROM 2 LABORATORIES [J].

ADLER, ID ;

KLIESCH, U ;

VANHUMMELEN, P ;

KIRSCHVOLDERS, M .

MUTAGENESIS, 1991, 6 (01) :47-53

[4] SPERMATID MICRONUCLEUS ANALYSES OF TRICHLOROETHYLENE AND CHLORAL HYDRATE EFFECTS IN MICE [J].

ALLEN, JW ;

COLLINS, BW ;

EVANSKY, PA .

MUTATION RESEARCH, 1994, 323 (1-2) :81-88

[5]

[Anonymous], 1995, IARC Monogr Eval Carcinog Risks Hum, V63, P75

[6]

Beland F A, 1999, Toxic Rep Ser, P1

[7] THE ANALYSIS OF 10 POTENTIAL SPINDLE POISONS FOR THEIR ABILITY TO INDUCE CREST-POSITIVE MICRONUCLEI IN HUMAN-DIPLOID FIBROBLASTS [J].

BONATTI, S ;

CAVALIERI, Z ;

VIAGGI, S ;

ABBONDANDOLO, A .

MUTAGENESIS, 1992, 7 (02) :111-114

[8]

Boveri T., 1914, Zur Frage der Entstehung Maligner Tumoren

[9] Comparison of lytic cocktail, chloral hydrate and midazolam for pediatric sedation [J].

Çaksen, H ;

Üner, A ;

Cesur, Y ;

Abuhandan, M ;

Çelebi, V ;

Sar, S .

JOURNAL OF TROPICAL PEDIATRICS, 2001, 47 (05) :316-316

[10] MOLECULAR-GENETICS OF HUMAN CANCER PREDISPOSITION AND PROGRESSION [J].

CAVENEE, WK ;

SCRABLE, HJ ;

JAMES, CD .

MUTATION RESEARCH, 1991, 247 (02) :199-202

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