Apoptotic Cell-Derived extracellular vesicles: More Than Just Debris

被引：395
作者：
Caruso, Sarah [1 ]
Poon, Ivan K. H. [1 ]
机构：
[1] La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem & Genet, Melbourne, Vic, Australia
来源：
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
基金：
英国医学研究理事会; 澳大利亚研究理事会;
关键词：
apoptotic bodies; apoptotic microvesicles; extracellular vesicles; immunomodulation; apoptosis; SYSTEMIC-LUPUS-ERYTHEMATOSUS; EXOSOME-LIKE VESICLES; CD8(+) T-CELLS; DENDRITIC CELLS; MEMBRANE MICROPARTICLES; ANTIGEN PRESENTATION; IMMUNE-RESPONSES; LYMPHOCYTES; CLEARANCE; MACROPHAGES;
D O I：
10.3389/fimmu.2018.01486
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The many functions of extracellular vesicles (EVs) like exosomes and microvesicles released from healthy cells have been well characterized, particularly in relation to their roles in immune modulation. Apoptotic bodies, a major class of EV released as a product of apoptotic cell disassembly, and other types of EVs released from dying cells are also becoming recognized as key players in this emerging field. There is now increasing evidence to suggest that EVs produced during apoptosis have important immune regulatory roles, a concept relevant across different disease settings including autoimmunity, cancer, and infection. Therefore, this review focuses on how the formation of EVs during apoptosis could be a key mechanism of immune modulation by dying cells.
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页数：9
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