Precision Medicine in Low- and Middle-Income Countries

被引：23

作者：

Radich, Jerald P. ^{[1
,2
,3
]}

Briercheck, Edward ^{[1
,2
]}

Chiu, Daniel T. ^{[4
,5
]}

Menon, Manoj P. ^{[1
,2
,3
,6
]}

Torra, Olga Sala ^{[2
]}

Yeung, Cecilia C. S. ^{[2
,3
]}

Warren, Edus H. ^{[1
,2
,3
,6
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Global Oncol Program, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, Clin Res Div, Seattle, WA 98109 USA

[3] Univ Washington, Sch Med, Seattle, WA 98195 USA

[4] Univ Washington, Dept Chem, Seattle, WA 98195 USA

[5] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[6] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2022年 / 17卷

基金：

美国国家卫生研究院;

关键词：

precision medicine; LMICs; diagnostics; CHRONIC MYELOID-LEUKEMIA; TYROSINE KINASE INHIBITORS; BREAST HEALTH-CARE; GUIDELINE IMPLEMENTATION; MESSENGER-RNA; CML PATIENTS; CANCER; IMATINIB; DIAGNOSIS; LYMPHOMA;

D O I：

10.1146/annurev-pathol-042320-034052

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Most cancer cases occur in low- and middle-income countries (LMICs). The sophisticated technical and human infrastructure needed for optimal diagnosis, treatment, and monitoring of cancers is difficult enough in affluent countries; it is especially challenging in LMICs. In Western, educated, industrial, rich, democratic countries, there is a growing emphasis on and success with precision medicine, whereby targeted therapy is directed at cancers based on the specific genetic lesions in the cancer. Can such precision approaches be delivered in LMICs? We offer some examples of novel partnerships and creative solutions that suggest that precision medicine may be possible in LMICs given heavy doses of will, creativity, and persistence and a little luck.

引用

页码：387 / 402

页数：16

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