Intraocular hemorrhage developing during interferon therapy

被引:11
作者
Kuga, K
Hasumura, S
Nagamori, S
Toda, G
Kitahara, K
机构
[1] First Dept. of Internal Medicine, Jikei University, School of Medicine, Tokyo
[2] Department of Ophthalmology, Jikei University, School of Medicine, Tokyo
[3] First Dept. of Internal Medicine, Jikei University, School of Medicine, Minato-ku, Tokyo 105
关键词
chronic active hepatitis C; interferon; ocular hemorrhage;
D O I
10.2169/internalmedicine.35.15
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 43-year-old man with chronic active hepatitis C was treated with interferon-beta (IFN-beta) at a dosage of 6x10(6) IU/day for a planned 6-week period. Ocular hyperemia, ophthalmalgia, and increased intraocular pressure in the right eye developed 20 days after the start of treatment. Intraocular pressure remained high, even after discontinuation of IFN therapy, laser therapy, and iridectomy. Two days later, the right eye was removed because perforation had occurred. The ocular symptoms that developed in this case were thought to have been caused and exacerbated by IFN administration.
引用
收藏
页码:15 / 18
页数:4
相关论文
共 14 条
[1]  
AVERBUCH SD, 1984, NEW ENGL J MED, V32, P310
[2]  
FURUE H, 1984, JAPANESE J CANC CHEM, V11, P186
[3]   INTERFERON-ASSOCIATED RETINOPATHY [J].
GUYER, DR ;
TIEDEMAN, J ;
YANNUZZI, LA ;
SLAKTER, JS ;
PARKE, D ;
KELLEY, J ;
TANG, RA ;
MARMOR, M ;
ABRAMS, G ;
MILLER, JW ;
GRAGOUDAS, ES .
ARCHIVES OF OPHTHALMOLOGY, 1993, 111 (03) :350-356
[4]  
IKEBE T, 1990, Folia Ophthalmologica Japonica, V41, P2291
[5]  
KADO M, 1994, JAP J CLIN OPHTHALMO, V48, P692
[6]  
KOGA M, 1989, J CLIN EXPT MED, V151, P871
[7]  
MIYAMOTO K, 1993, J EYE, V10, P497
[8]  
RETSAS S, 1983, CANCER, V51, P273, DOI 10.1002/1097-0142(19830115)51:2<273::AID-CNCR2820510218>3.0.CO
[9]  
2-K
[10]   TOXICITY OF INTERFERON [J].
SCOTT, GM ;
SECHER, DS ;
FLOWERS, D ;
BATE, J ;
CANTELL, K ;
TYRRELL, DAJ .
BRITISH MEDICAL JOURNAL, 1981, 282 (6273) :1345-1348