Reduced Graphene Oxide Nanosheet for Chemo-photothermal Therapy

被引：116
作者：
Cheon, Yeong Ah [1 ]
Bae, Jun Hyuk [1 ]
Chung, Bong Geun [1 ]
机构：
[1] Sogang Univ, Dept Mech Engn, Seoul 121742, South Korea
来源：
LANGMUIR | 2016年 / 32卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
DRUG-DELIVERY; CONTROLLED-RELEASE; DOXORUBICIN; CANCER; NANOCOMPOSITES; CYTOTOXICITY; FABRICATION; GREEN; CELLS;
D O I：
10.1021/acs.langmuir.6b00315
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The protein-functionalized reduced graphene oxide (rGO) nanosheet is of great interest in stimuli-responsive drug delivery and controlled release applications. We developed doxorubicin (DOX)-loaded bovine serum albumin (BSA)-functionalized rGO (DOX-BSA-rGO) nanosheets. To investigate the reduction of BSA-functionalized GO nanosheets and drug loading efficiency, we used X-ray photoelectron spectroscopy (XPS) and UV-visible spectrophotometer analysis. DOX-BSA-rGO nanosheets exhibited dose-dependent cellular uptake without any cytotoxic effect. We also demonstrated near infrared (NIR)-induced chemo-photothermal therapy of brain tumor cells treated with DOX-BSA-rGO nanosheets. Therefore, this DOX-BSA-rGO nanosheet could be a powerful tool for chemo-photothermal therapy applications.
引用
收藏
页码：2731 / 2736
页数：6
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