Perfluorocarbon attenuates inflammatory cytokines, oxidative stress and histopathologic changes in paraquat-induced acute lung injury in rats

被引：25

作者：

Khalighi, Zahra ^{[1
]}

Rahmani, Asghar ^{[2
]}

Cheraghi, Javad ^{[3
]}

Ahmadi, Mohammad Reza Hafezi ^{[4
]}

Soleimannejad, Koroush ^{[5
]}

Asadollahi, Ruhangiz ^{[4
]}

Asadollahi, Khairollah ^{[6
]}

机构：

[1] Ilam Univ Med Sci, Dept Internal Med, Fac Med, Ilam, Iran

[2] Ilam Univ Med Sci, Student Res Comm, Ilam, Iran

[3] Ilam Univ, Fac Vet, Dept Physiol, Ilam, Iran

[4] Ilam Univ Med Sci, Fac Med, Dept Pathol, Ilam, Iran

[5] Ilam Univ Med Sci, Fac Med, Dept Cardiol, Ilam, Iran

[6] Ilam Univ Med Sci, Fac Med, Dept Epidemiol, Ilam, Iran

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2016年 / 42卷

关键词：

Lung; Paraquat; Perfluorocarbon; Inflammation; Malondealdehyde; Histopathology; PULMONARY; ACTIVATION; INHALATION; INDUCTION; ISCHEMIA;

D O I：

10.1016/j.etap.2015.12.002

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effects of perfluorocarbon (PFC) on paraquat (PQ) induced acute lung injury (ALI) was evaluated among rats. Twenty four Wistar rats were divided into 4 groups: control group injected by saline physiologic 0.9%, PFC group injected by Perfluorocarbon, PQ group injected by PQ and PQ+ PFC group injected by PFC one hour after receiving paraquat. Bronchoalveular fluid content, inflammatory cytokines, oxidative and histopathologic changes were measured after 72 h. The levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta(TGF-beta 1) in the PQ group were increased compared to either control or PFC groups, but their levels decreased in PQ+ PFC group significantly (p <0.05). Also, histopathologic evaluation revealed an increase in malondialdehyde (MDA) and hydroxyproline (HP) in the PQ group but a decrease in PQ+PFC group significantly (p < 0.01). PFC emulsion by its anti-inflammatory, anti-oxidative and anti-fibrotic properties can reduce the inflammatory and fibrotic alterations, pulmonary oedema, and pulmonary histopathologic changes created by PQ (C)2015 Elsevier B.V. All rights reserved.

引用

页码：9 / 15

页数：7

共 32 条

[1] Endobronchial perfluorocarbon administration decreases lung injury in an experimental model of ischemia and reperfusion [J].