Haem-oxygen reactive intermediates: catalysis by the two-step

被引：9
作者：
Makris, TM
Denisov, IG
Sligar, SG [1 ]
机构：
[1] Univ Illinois, Dept Biochem, 505 S Goodwin Ave, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
[3] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA
[4] Univ Illinois, Coll Med, Urbana, IL 61801 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷
关键词：
dioxygen activation; P450; mechanism;
D O I：
10.1042/BST0310516
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The catalytic schemes of a variety of haem enzymes, including the P450 mono-oxygenases, consist of a number of common reactive haem-oxygen adducts. The characterization of these intermediates by optical and EPR spectroscopies has reinforced the similarity of these intermediate states in a number of haem enzyme systems. Furthermore, the reactivity of these states in P450 and horseradish peroxidase, in which multiple potent oxidants are formed, provides a paradigm for many other haem enzymes.
引用
收藏
页码：516 / 519
页数：4
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