Solitary Epstein-Barr virus-positive cytotoxic T cell lymphoproliferative disease in stomach mimicking extranodal NK/T cell lymphoma

Epstein-Barr virus (EBV)-associated lymphoid tissue diseases are complex disorders, presenting EBV-related immunodeficiency and non-immunodeficiency symptoms and signs; the latter includes benign lymphoid tissue hyperplastic disorders, EBV-related lymphoma, and EBV-positive lymphoproliferative diseases (LPDs). Herein, we report a case of a 52-year-old female who had an epigastric pain, with occasional acid regurgitation and nausea, and was diagnosed with gastric solitary EBV-positive cytotoxic T cell lymphoproliferative disease. The patient was treated with radical gastrectomy, without aggressive chemotherapy, and had disease-free survival of 14 months (based on the last follow-up). To our best knowledge, this was the first report of solitary EBV-positive cytotoxic T cell LPD in stomach. Our findings suggest that EBV+T cell LPD could be present as focal or solitary disease.