Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer

被引：19

作者：

Chichirau, Bianca E. ^{[1
]}

Diechler, Sebastian ^{[1
]}

Posselt, Gernot ^{[1
]}

Wessler, Silja ^{[2
]}

机构：

[1] Paris Lodron Univ Salzburg, Dept Biosci, A-5020 Salzburg, Austria

[2] Paris Lodron Univ Salzburg, Dept Biosci, Canc Cluster Salzburg, A-5020 Salzburg, Austria

来源：

TOXINS | 2019年 / 11卷 / 10期

基金：

奥地利科学基金会;

关键词：

Helicobacter pylori; tyrosine kinases; c-Abl; CagA; Src family kinases; EGFR; c-Met; EPIDERMAL-GROWTH-FACTOR; FOCAL ADHESION KINASE; CAG-PATHOGENICITY ISLAND; IV SECRETION SYSTEM; C-ABL; FACTOR RECEPTOR; EPITHELIAL-CELLS; EFFECTOR PROTEIN; MET RECEPTOR; PHOSPHORYLATION;

D O I：

10.3390/toxins11100591

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Helicobacter pylori (H. pylori) has been identified as a leading cause of gastric cancer, which is one of the most frequent and malignant types of tumor. It is characterized by its rapid progression, distant metastases, and resistance to conventional chemotherapy. A number of receptor tyrosine kinases and non-receptor tyrosine kinases have been implicated in H. pylori-mediated pathogenesis and tumorigenesis. In this review, recent findings of deregulated EGFR, c-Met, JAK, FAK, Src, and c-Abl and their functions in H. pylori pathogenesis are summarized.

引用

页数：15

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