Neural correlates of emotion processing during observed self-face recognition in individuals with autism spectrum disorders

被引：9

作者：

Morita, Tomoyo ^{[1
,2
]}

Kosaka, Hirotaka ^{[3
,4
,5
]}

Saito, Daisuke N. ^{[3
,5
]}

Fujii, Takeshi ^{[3
,5
,6
]}

Ishitobi, Makoto ^{[4
,7
]}

Munesue, Toshio ^{[8
]}

Inohara, Keisuke ^{[4
,9
]}

Okazawa, Hidehiko ^{[3
,5
]}

Kakigi, Ryusuke ^{[1
]}

Sadato, Norihiro ^{[5
,10
,11
]}

机构：

[1] Natl Inst Physiol Sci, Dept Integrat Physiol, Okazaki, Aichi 4448585, Japan

[2] Osaka Univ, Grad Sch Engn, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[3] Univ Fukui, Res Ctr Child Mental Dev, Fukui 9101193, Japan

[4] Univ Fukui, Dept Neumpsychiat, Fac Med Sci, Fukui 9101193, Japan

[5] Univ Fukui, Biomed Imaging Res Ctr, Fukui 9101193, Japan

[6] Natl Ctr Neurol & Psychiat Hosp, Dept Psychiat, Kodaira, Tokyo 1878551, Japan

[7] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Child & Adolescent Mental Hlth, Kodaira, Tokyo 1878553, Japan

[8] Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa 9208641, Japan

[9] Univ Electrocommun, Grad Sch Informat & Engn, Dept Informat, Chofu, Tokyo 1828585, Japan

[10] Natl Inst Physiol Sci, Dept Cerebral Res, Okazaki, Aichi 4448585, Japan

[11] Grad Univ Adv Studies Sokendai, Dept Physiol Sci, Okazaki, Aichi 4448585, Japan

来源：

RESEARCH IN AUTISM SPECTRUM DISORDERS | 2016年 / 26卷

基金：

日本学术振兴会;

关键词：

Anterior cingulate cortex; Anterior insula; Autism spectrum disorder (ASD); Being observed; Embarrassment; Functional magnetic resonance imaging; Self-face; COMMUNICATION DISORDERS; DIAGNOSTIC INTERVIEW; PREFRONTAL CORTEX; SOCIAL COGNITION; FMRI; BRAIN; ACTIVATION; NETWORKS; INSULA; CONSCIOUSNESS;

D O I：

10.1016/j.rasd.2016.02.011

中图分类号：

G76 [特殊教育];

学科分类号：

040109 ;

摘要：

When exposed to self-face images, individuals often experience embarrassment, which is enhanced by being observed. This self-evaluative emotion is related to activity in the right anterior insula and the functional connectivity between the anterior cingulate and prefrontal cortices. Coupling between cognitive evaluation of self-face images and emotional response to them (cognitive-emotional coupling) is weaker in individuals with autism spectrum disorder (ASD), in parallel with reduced activity of the right insula. To determine whether self-evaluative emotions of individuals with ASD are less strongly impacted by observation, we conducted functional MRI in 14 adult men with ASD and 18 age-matched control men while the participants viewed self-face images. Increased embarrassment upon observation was positively correlated with increased activity in the right anterior insula in the control group, but not in the ASD group. In addition, awareness of being observed enhanced cognitive-emotional coupling in the controls but not in the ASD group. The coupling was correlated with the functional connectivity between the anterior cingulate and medial prefrontal cortices. These results suggest that the reduced impact of observation on embarrassment induced by self-face images in individuals with ASD is related to impairment in the right anterior insula, which is involved in creating subjective feelings, and the anterior cingulate cortex, which acts as a hub for integrating information from others during self-face evaluation. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：16 / 32

页数：17

共 84 条

[1] Meeting of minds: the medial frontal cortex and social cognition [J].

Amodio, DM ;

Frith, CD .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (04) :268-277

[2]

[Anonymous], 1972, THEORY OBJECTIVE SEL

[3]

[Anonymous], HUMAN SCI RES KOBE U

[4]

[Anonymous], 2000, HDB EMOTIONS

[5]

[Anonymous], 2006, A Japanese Version of the WAISIII

[6]

[Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787

[7] The Autism-Spectrum Quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians [J].

Baron-Cohen, S ;

Wheelwright, S ;

Skinner, R ;

Martin, J ;

Clubley, E .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2001, 31 (01) :5-17

[8] The neural correlates of maternal and romantic love [J].

Bartels, A ;

Zeki, S .

NEUROIMAGE, 2004, 21 (03) :1155-1166

[9] Cues of being watched enhance cooperation in a real-world setting [J].

Bateson, Melissa ;

Nettle, Daniel ;

Roberts, Gilbert .

BIOLOGY LETTERS, 2006, 2 (03) :412-414

[10] Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion [J].

Blood, AJ ;

Zatorre, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) :11818-11823

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