A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study

被引：15

作者：

Rose, Louise ^{[1
]}

Burry, Lisa ^{[2
,3
]}

Agar, Meera ^{[4
]}

Blackwood, Bronagh ^{[5
]}

Campbell, Noll L. ^{[6
]}

Clarke, Mike ^{[7
]}

Devlin, John W. ^{[8
]}

Lee, Jacques ^{[9
]}

Marshall, John C. ^{[10
,11
]}

Needham, Dale M. ^{[12
]}

Siddiqi, Najma ^{[13
]}

Page, Valerie ^{[14
]}

机构：

[1] Kings Coll London, Florence Nightingale Fac Nursing Midwifery & Pall, Rm 1-13,James Clerk Maxwell Bldg,57 Waterloo Rd, London SE1 8WA, England

[2] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada

[3] Sinai Hlth Syst, Mt Sinai Hosp, Toronto, ON, Canada

[4] Univ Technol Sydney, Fac Hlth, Sydney, NSW, Australia

[5] Queens Univ Belfast, Wellcome Wolfson Inst Expt Med, Belfast, Antrim, North Ireland

[6] Purdue Univ, Coll Pharm, W Lafayette, IN 47907 USA

[7] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Belfast, Antrim, North Ireland

[8] Northeastern Univ, Sch Pharm, Boston, MA USA

[9] Sinai Hlth Syst, Inaugural Res Chair Geriatr Emergency Med, Schwartz Reisman Emergency Med Inst, Toronto, ON, Canada

[10] St Michaels Hosp, Toronto, ON, Canada

[11] Li Ka Shing Res Inst, Toronto, ON, Canada

[12] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[13] Univ York, Hull York Med Sch, York, N Yorkshire, England

[14] Watford Dist Gen Hosp, Watford, England

来源：

BMC MEDICINE | 2021年 / 19卷 / 01期

基金：

英国医学研究理事会; 加拿大健康研究院;

关键词：

Delirium; Hospitalization; Core outcome set; Clinical trials; POSTOPERATIVE DELIRIUM; CRITICALLY-ILL; MORTALITY; DIAGNOSIS; DEMENTIA;

D O I：

10.1186/s12916-021-02015-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Trials of interventions to prevent or treat delirium in adults in an acute hospital setting report heterogeneous outcomes. Our objective was to develop international consensus among key stakeholders for a core outcome set (COS) for future trials of interventions to prevent and/or treat delirium in adults with an acute care hospital admission and not admitted to an intensive care unit. Methods: A rigorous COS development process was used including a systematic review, qualitative interviews, modified Delphi consensus process, and in-person consensus using nominal group technique (registration registration http://www.comet- initiative.org/studies/details/796). Participants in qualitative interviews were delirium survivors or family members. Participants in consensus methods comprised international representatives from three stakeholder groups: researchers, clinicians, and delirium survivors and family members. Results: Item generation identified 8 delirium-specific outcomes and 71 other outcomes from 183 studies, and 30 outcomes from 18 qualitative interviews, including 2 that were not extracted from the systematic review. De-duplication of outcomes and formal consensus processes involving 110 experts including researchers (N = 32), clinicians (N = 63), and delirium survivors and family members (N = 15) resulted in a COS comprising 6 outcomes: delirium occurrence and reoccurrence, delirium severity, delirium duration, cognition, emotional distress, and health-related quality of life. Study limitations included exclusion of non-English studies and stakeholders and small representation of delirium survivors/family at the in-person consensus meeting. Conclusions: This COS, endorsed by the American and Australian Delirium Societies and European Delirium Association, is recommended for future clinical trials evaluating delirium prevention or treatment interventions in adults presenting to an acute care hospital and not admitted to an intensive care unit.

引用

页数：11

共 42 条

[21] Delirium superimposed on dementia: A quantitative and qualitative evaluation of patient experience [J].