Amplicons on chromosome 12q13-21 in glioblastoma recurrences

被引:26
作者
Fischer, Ulrike [1 ]
Leidinger, Petra [1 ]
Keller, Andreas [2 ]
Folarin, Amos [3 ]
Keller, Ralf [4 ]
Graf, Norbert [5 ]
Lenhof, Hans-Peter [2 ]
Meese, Eckart [1 ]
机构
[1] Univ Saarland, Dept Human Genet, D-66421 Homburg, Germany
[2] Univ Saarland, Ctr Bioinformat, D-66123 Saarbrucken, Germany
[3] UCL, UCL Canc Inst, London WC1E 6BT, England
[4] Univ Saarland, Dept Neurosurg, D-66421 Homburg, Germany
[5] Univ Saarland, Dept Pediat Hematol & Oncol, D-66421 Homburg, Germany
关键词
genomic array hybridization; glioblastoma; recurrences; HUMAN-MALIGNANT GLIOMAS; AMPLIFICATION; CONCOMITANT; EVOLUTION; PROFILES; FREQUENT; TUMOR;
D O I
10.1002/ijc.24971
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
There is limited knowledge on the in vivo behavior of amplified regions in human tumors. First evidence indicates that amplicon structures are largely maintained in recurrent tumors. Here, we investigated the fate of amplified regions in several independent cases of recurrent glioblastoma and the possible association of 12q13-21 amplifications and survival. We analyzed 12q13-21 amplicon numbers and sizes in glioblastoma and their recurrences by array-CGH. The majority of the 12q13-21 amplicons found in the original tumor are lost in the subsequent recurrence. Likewise, the majority of the amplicons found in the first recurrence are lost in the second recurrence. The remaining amplicons of recurrences often expanded or were maintained in size. Because of re-emergences and de novo appearances of amplicons, however, the overall number of amplicons did not decrease in the recurrences. Understanding genetic changes including gene amplifications in the development of tumor recurrences will contribute to rational therapeutic strategies for an improved patient survival. We recognized a significant longer survival time in glioblastoma patients that lack amplifications of either CDK4, CYP27B1, XRCC6BP1 (KUB3), or MDM2.
引用
收藏
页码:2594 / 2602
页数:9
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