The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro

被引：16
作者：
Demiroglu-Zergeroglu, A. [1 ]
Basara-Cigerim, B. [1 ]
Kilic, E. [2 ,3 ]
Yanikkaya-Demirel, G.
机构：
[1] Gebze Inst Technol, Dept Biol, Fac Sci, TR-41400 Gebze, Kocaeli, Turkey
[2] Erciyes Univ, Dept Clin Biochem, TR-38039 Kayseri, Turkey
[3] Istanbul Ctr Labs, TR-34400 Istanbul, Turkey
来源：
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2010年
关键词：
INDUCED GROWTH-INHIBITION; FOOD-DERIVED POLYPHENOLS; ESTROGEN-BINDING SITES; CYTOCHROME-C RELEASE; COLON-CANCER CELLS; LEUKEMIA-CELLS; PLEURAL MESOTHELIOMA; CYCLE ARREST; MOLECULAR TARGETS; APOPTOSIS;
D O I：
10.1155/2010/851589
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines. Our experiments showed that QU significantly reduced the proliferation of cell lines, altered the cell cycle distribution, and increased the level of Caspase 9 (C9) and Caspase 3 (C3) in concentration and time-dependent manner. Additionally, the combination of QU + CIS was found more e. ective when compared with individual treatment of agents.
引用
收藏
页数：7
相关论文
共 43 条
[1]  
AVILA MA, 1994, CANCER RES, V54, P2424
[2]   Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents [J].
Chan, MM ;
Fong, D ;
Soprano, KJ ;
Holmes, WF ;
Heverling, H .
JOURNAL OF CELLULAR PHYSIOLOGY, 2003, 194 (01) :63-70
[3]   Antiproliferative Effects of Quercetin through Cell Cycle Arrest and Apoptosis in Human Breast Cancer MDA-MB-453 Cells [J].
Choi, Eun Jeong ;
Bae, Su Mi ;
Ahn, Woong Shick .
ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (10) :1281-1285
[4]  
Choi JA, 2001, INT J ONCOL, V19, P837
[5]  
Cipák L, 2003, LEUKEMIA RES, V27, P65, DOI 10.1016/S0145-2126(02)00063-2
[6]   Enhanced effectiveness of last generation antiblastic compounds vs. cisplatin on malignant pleural mesothelioma cell lines [J].
de Cupis, A ;
Semino, C ;
Pirani, P ;
Loprevite, M ;
Ardizzoni, A ;
Favoni, RE .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 473 (2-3) :83-95
[7]  
DOWELL J, 2009, J CLIN ONCOL, V27, pS401
[8]  
Elattar TMA, 2000, ANTICANCER RES, V20, P1733
[9]  
Ferrandina G, 1998, INT J CANCER, V77, P747, DOI 10.1002/(SICI)1097-0215(19980831)77:5<747::AID-IJC14>3.0.CO
[10]  
2-Z
12345