Bioanalytical applications of 'fast chromatography' to high-throughput liquid chromatography/tandem mass spectrometric quantitation

被引：0
作者：
Romanyshyn, L [1 ]
Tiller, PR [1 ]
Hop, CECA [1 ]
机构：
[1] Merck Res Labs, Drug Metab, Rahway, NJ 07065 USA
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2000年 / 14卷 / 18期
关键词：
D O I：
10.1002/1097-0231(20000930)14:18<1662::AID-RCM77>3.3.CO;2-E
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A fast chromatographic separation approach that enables rapid method development for high-throughput sample quantification is discussed. This approach has been used to analyze samples from various biological matrices. Data are presented from in vivo pharmaokinetic studies (plasma) and in vitro drug metabolism and transport studies (hepatic microsomes, hepatocytes, and Caco-2 cells). Copyright (C) 2000 John Wiley & Sons, Ltd.
引用
收藏
页码：1662 / 1668
页数：7
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