Nanotechnology in Radiation Oncology

被引：13

作者：

Sun, Bo ^{[1
]}

Hagan, C. Tilden ^{[2
]}

Caster, Joseph ^{[3
]}

Wang, Andrew Z. ^{[4
]}

机构：

[1] Univ N Carolina, Radiat Oncol, 125 Mason Farm Rd,Mars 2236, Chapel Hill, NC 27599 USA

[2] UNC NCSU Joint Dept Biomed Engn, 125 Mason Farm Rd,Mars 2120, Chapel Hill, NC 27599 USA

[3] Univ Iowa, Carver Coll Med, Radiat Oncol, 200 Hawkins Dr, Iowa City, IA 52242 USA

[4] Univ N Carolina, Radiat Oncol, 101 Manning Dr, Chapel Hill, NC 27599 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2019年 / 33卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Nanoparticles; Radiosensitization; Radiotherapy; Tumor imaging; Cancer biomarkers; Liquid biopsy; Circulating tumor cells; Circulating tumor DNA; CIRCULATING-TUMOR-CELLS; GADOLINIUM-BASED NANOPARTICLES; CANCER-TARGETED PROBES; INTRATUMOR HETEROGENEITY; SILICA NANOPARTICLES; CARBON NANOTUBES; PROGRESSION-FREE; NAB-PACLITAXEL; LIQUID BIOPSY; STEM-CELLS;

D O I：

10.1016/j.hoc.2019.08.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nanotechnology has made remarkable contributions to clinical oncology. Nanotherapeutics and diagnostic tools have distinctive characteristics which allow them superior abilities to deliver therapeutics and imaging agents for radiation oncology. Compared to solid biopsies and imaging, the analysis of circulating tumor cells (CTCs) offers a more rapid, real-time, and less invasive method to monitor the dynamic molecular profiles of tumors. The potential of CTCs to be translated as a novel cancer biomarker has been demonstrated in numerous clinical studies. This review will discuss clinical applications of nanomaterials in radiation oncology and the implication of CTCs in cancer detection and monitoring.

引用

页码：1071 / +

页数：25

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