High-Frequency Array-Based Nanobubble Nonlinear Imaging in a Phantom and In Vivo

被引:4
作者
Pellow, Carly [1 ,2 ,3 ]
Cherin, Emmanuel [3 ]
Abenojar, Eric C. [4 ]
Exner, Agata A. [4 ]
Zheng, Gang [1 ,2 ]
Demore, Christine E. M. [1 ,3 ]
Goertz, David E. [1 ,3 ]
机构
[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
[2] Princess Margaret Canc Res Ctr, Toronto, ON M5G 0A3, Canada
[3] Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada
[4] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA
基金
加拿大自然科学与工程研究理事会;
关键词
Scattering; Phantoms; Lipidomics; Ultrasonic imaging; Needles; High frequency; Acoustics; Amplitude modulation (AM); array transducer; high frequency; imaging; nanobubble (NB); ULTRASOUND CONTRAST AGENTS; PRESSURE-DEPENDENT ATTENUATION; PHOSPHOLIPID-COATED MICROBUBBLES; ACOUSTIC CHARACTERIZATION; ENCAPSULATING SHELLS; SUBHARMONIC RESPONSE; SCATTERING; BUBBLES;
D O I
10.1109/TUFFC.2021.3055141
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
There has been growing interest in nanobubbles (NBs) for vascular and extravascular ultrasound contrast imaging and therapeutic applications. Studies to date have generally utilized low frequencies (<12 MHz), high concentrations (>10(9) mL(-1)), and uncalibrated B-mode or contrast-mode on commercial systems without reporting investigations on NB signatures upon which the imaging protocols should be based. We recently demonstrated that low concentrations (10(6) mL(-1)) of porphyrin-lipid-encapsulated NBs scatter nonlinearly at low (2.5, 8 MHz) and high (12.5, 25, 30 MHz) frequencies in a pressure threshold-dependent manner that is advantageous for amplitude modulation (AM) imaging. Here, we implement pressure-calibrated AM at high frequency on a commercial preclinical array system to enhance sensitivity to nonlinear scattering of three phospholipid-based NB formulations. With this approach, improvements in contrast to tissue ratio relative to B-mode between 12.4 and 22.8 dB are demonstrated in a tissue-mimicking phantom, and between 6.7 and 14.8 dB in vivo.
引用
收藏
页码:2059 / 2074
页数:16
相关论文
共 79 条
  • [1] Theoretical and Experimental Gas Volume Quantification of Micro- and Nanobubble Ultrasound Contrast Agents
    Abenojar, Eric C.
    Bederman, Ilya
    de Leon, Al C.
    Zhu, Jinle
    Hadley, Judith
    Kolios, Michael C.
    Exner, Agata A.
    [J]. PHARMACEUTICS, 2020, 12 (03)
  • [2] Effect of Bubble Concentration on the in Vitro and in Vivo Performance of Highly Stable Lipid Shell-Stabilized Micro- and Nanoscale Ultrasound Contrast Agents
    Abenojar, Eric C.
    Nittayacharn, Pinunta
    de Leon, Al Christopher
    Perera, Reshani
    Wang, Yu
    Bederman, Ilya
    Exner, Agata A.
    [J]. LANGMUIR, 2019, 35 (31) : 10192 - 10202
  • [3] Acoustic radiation force induced accumulation and dynamics of microbubbles on compliant surfaces
    Acconcia, Christopher N.
    Leung, Ben Y. C.
    Winch, Gordon
    Wang, Julian
    Hynynen, Kullervo
    Goertz, David E.
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 2019, 64 (13)
  • [4] Update on the safety and efficacy of commercial ultrasound contrast agents in cardiac applications
    Appis A.W.
    Tracy M.J.
    Feinstein S.B.
    [J]. Echo Research & Practice, 2015, 2 (2) : R55 - R62
  • [5] The Optimized Fabrication of Nanobubbles as Ultrasound Contrast Agents for Tumor Imaging
    Cai, Wen Bin
    Yang, Heng Li
    Zhang, Jian
    Yin, Ji Kai
    Yang, Yi Lin
    Yuan, Li Jun
    Zhang, Li
    Duan, Yun You
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [6] Preparation and characterization of dextran nanobubbles for oxygen delivery
    Cavalli, R.
    Bisazza, A.
    Giustetto, P.
    Civra, A.
    Lembo, D.
    Trotta, G.
    Guiot, C.
    Trotta, M.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 381 (02) : 160 - 165
  • [7] Pressure-dependent attenuation in ultrasound contrast agents
    Chen, Q
    Zagzebski, J
    Wilson, T
    Stiles, T
    [J]. ULTRASOUND IN MEDICINE AND BIOLOGY, 2002, 28 (08) : 1041 - 1051
  • [8] ACOUSTIC BEHAVIOR OF HALOBACTERIUM SALINARUM GAS VESICLES IN THE HIGH-FREQUENCY RANGE: EXPERIMENTS AND MODELING
    Cherin, Emmanuel
    Melis, Johan M.
    Bourdeau, Raymond W.
    Yin, Melissa
    Kochmann, Dennis M.
    Foster, F. Stuart
    Shapiroz, Mikhail G.
    [J]. ULTRASOUND IN MEDICINE AND BIOLOGY, 2017, 43 (05) : 1016 - 1030
  • [9] High-speed optical observations and simulation results of SonoVue microbubbles at low-pressure insonation
    Chetty, Kevin
    Stride, Eleanor
    Sennoga, Charles A.
    Hajnal, Joseph V.
    Eckersley, Robert J.
    [J]. IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2008, 55 (06) : 1333 - 1342
  • [10] In vitro characterization of the subharmonic ultrasound signal from Definity microbubbles at high frequencies
    Cheung, K.
    Couture, O.
    Bevan, P. D.
    Cherin, E.
    Williams, R.
    Burns, P. N.
    Foster, F. S.
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 2008, 53 (05) : 1209 - 1223