High-Frequency Array-Based Nanobubble Nonlinear Imaging in a Phantom and In Vivo
被引:4
作者:
Pellow, Carly
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机构:
Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Princess Margaret Canc Res Ctr, Toronto, ON M5G 0A3, Canada
Sunnybrook Res Inst, Toronto, ON M4N 3M5, CanadaUniv Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Pellow, Carly
[1
,2
,3
]
Cherin, Emmanuel
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h-index: 0
机构:
Sunnybrook Res Inst, Toronto, ON M4N 3M5, CanadaUniv Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Cherin, Emmanuel
[3
]
Abenojar, Eric C.
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h-index: 0
机构:
Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USAUniv Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Abenojar, Eric C.
[4
]
Exner, Agata A.
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h-index: 0
机构:
Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USAUniv Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Exner, Agata A.
[4
]
Zheng, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Princess Margaret Canc Res Ctr, Toronto, ON M5G 0A3, CanadaUniv Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Zheng, Gang
[1
,2
]
Demore, Christine E. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Sunnybrook Res Inst, Toronto, ON M4N 3M5, CanadaUniv Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Demore, Christine E. M.
[1
,3
]
Goertz, David E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Sunnybrook Res Inst, Toronto, ON M4N 3M5, CanadaUniv Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
Goertz, David E.
[1
,3
]
机构:
[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
[2] Princess Margaret Canc Res Ctr, Toronto, ON M5G 0A3, Canada
[3] Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada
[4] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA
There has been growing interest in nanobubbles (NBs) for vascular and extravascular ultrasound contrast imaging and therapeutic applications. Studies to date have generally utilized low frequencies (<12 MHz), high concentrations (>10(9) mL(-1)), and uncalibrated B-mode or contrast-mode on commercial systems without reporting investigations on NB signatures upon which the imaging protocols should be based. We recently demonstrated that low concentrations (10(6) mL(-1)) of porphyrin-lipid-encapsulated NBs scatter nonlinearly at low (2.5, 8 MHz) and high (12.5, 25, 30 MHz) frequencies in a pressure threshold-dependent manner that is advantageous for amplitude modulation (AM) imaging. Here, we implement pressure-calibrated AM at high frequency on a commercial preclinical array system to enhance sensitivity to nonlinear scattering of three phospholipid-based NB formulations. With this approach, improvements in contrast to tissue ratio relative to B-mode between 12.4 and 22.8 dB are demonstrated in a tissue-mimicking phantom, and between 6.7 and 14.8 dB in vivo.
机构:
Division of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, ILDivision of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, IL
Appis A.W.
Tracy M.J.
论文数: 0引用数: 0
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机构:
Division of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, ILDivision of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, IL
Tracy M.J.
Feinstein S.B.
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h-index: 0
机构:
Division of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, ILDivision of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, IL
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Cai, Wen Bin
Yang, Heng Li
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h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Yang, Heng Li
Zhang, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Zhang, Jian
Yin, Ji Kai
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Gen Surg, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Yin, Ji Kai
Yang, Yi Lin
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Yang, Yi Lin
Yuan, Li Jun
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Yuan, Li Jun
Zhang, Li
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h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Zhang, Li
Duan, Yun You
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h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
机构:
Sunnybrook Res Inst, Phys Sci, Toronto, ON, CanadaSunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Cherin, Emmanuel
Melis, Johan M.
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USASunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Melis, Johan M.
Bourdeau, Raymond W.
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USASunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Bourdeau, Raymond W.
Yin, Melissa
论文数: 0引用数: 0
h-index: 0
机构:
Sunnybrook Res Inst, Phys Sci, Toronto, ON, CanadaSunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Yin, Melissa
Kochmann, Dennis M.
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h-index: 0
机构:
CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USASunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Kochmann, Dennis M.
Foster, F. Stuart
论文数: 0引用数: 0
h-index: 0
机构:
Sunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Univ Toronto, Dept Med Biophys, Toronto, ON, CanadaSunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Foster, F. Stuart
Shapiroz, Mikhail G.
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USASunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
机构:
Division of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, ILDivision of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, IL
Appis A.W.
Tracy M.J.
论文数: 0引用数: 0
h-index: 0
机构:
Division of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, ILDivision of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, IL
Tracy M.J.
Feinstein S.B.
论文数: 0引用数: 0
h-index: 0
机构:
Division of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, ILDivision of Cardiology, Rush University, Medical Center, 1653 West Congress Parkway, Chicago, 60612, IL
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Cai, Wen Bin
Yang, Heng Li
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Yang, Heng Li
Zhang, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Zhang, Jian
Yin, Ji Kai
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Gen Surg, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Yin, Ji Kai
Yang, Yi Lin
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Yang, Yi Lin
Yuan, Li Jun
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Yuan, Li Jun
Zhang, Li
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
Zhang, Li
Duan, Yun You
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710032, Shaanxi, Peoples R China
机构:
Sunnybrook Res Inst, Phys Sci, Toronto, ON, CanadaSunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Cherin, Emmanuel
Melis, Johan M.
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USASunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Melis, Johan M.
Bourdeau, Raymond W.
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USASunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Bourdeau, Raymond W.
Yin, Melissa
论文数: 0引用数: 0
h-index: 0
机构:
Sunnybrook Res Inst, Phys Sci, Toronto, ON, CanadaSunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Yin, Melissa
Kochmann, Dennis M.
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USASunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Kochmann, Dennis M.
Foster, F. Stuart
论文数: 0引用数: 0
h-index: 0
机构:
Sunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Univ Toronto, Dept Med Biophys, Toronto, ON, CanadaSunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
Foster, F. Stuart
Shapiroz, Mikhail G.
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USASunnybrook Res Inst, Phys Sci, Toronto, ON, Canada