Synthesis and applications of HexaPHEMP, a novel biaryl diphosphine ligand

被引：105

作者：

Henschke, JP ^{[1
]}

Burk, MJ ^{[1
]}

Malan, CG ^{[1
]}

Herzberg, D ^{[1
]}

Peterson, JA ^{[1
]}

Wildsmith, AJ ^{[1
]}

Cobley, CJ ^{[1
]}

Casy, G ^{[1
]}

机构：

[1] Chirotech Technol Ltd, Pharmaceut Serv, Cambridge CB4 0WG, England

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2003年 / 345卷 / 1-2期

关键词：

asymmetric catalysis; asymmetric hydrogenation; biaryldiphosphine; HexaPHEMP; P-ligands; ruthenium;

D O I：

10.1002/adsc.200390025

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The novel biaryldiphosphine ligand 1 (Hexa-PHEMP) has been prepared in five steps from commercially available 3,4,5-trimethylphenol using a concise synthetic route. This approach also allows fine tuning of the ligand's stereoelectronic properties through the variation of the aromatic groups on the ligating phosphorus atoms. In certain asymmetric hydrogenation processes, catalysts containing this ligand were found to have enhanced activity and selectivity over other biaryldiphosphine-containing catalysts.

引用

页码：300 / 307

页数：8

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