Five-year resistance trends in pathogens causing healthcare-associated infections at a multi-hospital healthcare system in Saudi Arabia, 2015-2019

被引:19
作者
Al Mutair, Abbas [1 ,2 ,3 ]
Alhumaid, Saad [4 ]
Alawi, Zainab Al [5 ]
Zaidi, Abdul Rehman Z. [6 ,7 ]
Alzahrani, Ahmed J. [8 ]
Al-Tawfiq, Jaffar A. [9 ,10 ,11 ]
Al-Shammari, Haifa [12 ]
Rabaan, Ali A. [13 ]
Khojah, Osamah [14 ,15 ]
Al-Omari, Awad [6 ,7 ]
机构
[1] Almoosa Specialist Hosp, Res Ctr, Dharan St,POB 5098, Al Hasa, Eastern Provinc, Saudi Arabia
[2] Princess Nora Univ, Coll Nursing, Riyadh, Saudi Arabia
[3] Univ Wollongong, Sch Nursing, Wollongong, NSW, Australia
[4] Al Ahsa Hlth Cluster, Adm Pharmaceut Care, Minist Hlth, Al Hasa, Saudi Arabia
[5] King Faisal Univ, Dept Pediat, Coll Med, Al Hasa, Saudi Arabia
[6] Dr Sulaiman Al Habib Med Grp, Res Ctr, Riyadh, Saudi Arabia
[7] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia
[8] Imam Mohammed Ibn Saud Islamic Univ, Dept Pathol, Coll Med, Riyadh, Saudi Arabia
[9] Johns Hopkins Aramco Healthcare, Infect Dis Unit, Specialty Internal Med & Infect Control Unit, Qual & Patient Safety, Dhahran, Saudi Arabia
[10] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA
[11] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD USA
[12] King Saud Med City, Dept Histopathol, Riyadh, Saudi Arabia
[13] Johns Hopkins Aramco Healthcare, Mol Diagnost Lab, Dhahran, Saudi Arabia
[14] King Saud Univ, Dept Pathol, Coll Med, Riyadh, Saudi Arabia
[15] Dr Sulaiman Al Habib Med Grp, Lab Serv, Riyadh, Saudi Arabia
关键词
Antimicrobial resistance; Antibacterial agents; Isolates; Pathogens; Multidrug resistance; Saudi Arabia; GRAM-NEGATIVE BACTERIA; VENTILATOR-ASSOCIATED PNEUMONIA; ANTIMICROBIAL RESISTANCE; ACINETOBACTER-BAUMANNII; PSEUDOMONAS-AERUGINOSA; KLEBSIELLA-PNEUMONIAE; MULTIDRUG-RESISTANCE; HOSPITALS; PREVALENCE; ENTEROBACTERIACEAE;
D O I
10.1016/j.jgar.2021.03.009
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: Awareness of antimicrobial resistance (AMR) patterns in a given healthcare setting is important to inform the selection of appropriate antimicrobial therapy to reduce the further rise and spread of AMR as well as the rate of healthcare-associated infections (HAIs) and multidrug-resistant (MDR) organisms. We aimed to describe resistance patterns to several antimicrobial agents in pathogens causing HAIs isolated from patients using data gathered at three private tertiary-care hospitals in Saudi Arabia. Methods: Data on trends in AMR among bacteria causing HAIs and MDR events in children and adults at three private hospitals were collected retrospectively (2015-2019) using surveillance data. Results: Over the 5-year period, 29 393 pathogens caused 17 539 HAIs in 15 259 patients. Approximately 57.3% of patients were female and the mean age was 38.4 +/- 16.8 years (81.4% adults, 18.6% children). Gram-negative pathogens were four times more likely to cause HAIs compared with Gram-positive bacteria (79.3% vs. 20.7%). Ranking of causative pathogens in decreasing order was Escherichia coli (42.2%), Klebsiella spp. (16.8%) and Staphylococcus aureus (13.9%). Acinetobacter spp. were the only pathogens to decrease significantly (7% reduction; P = 0.033). The most common resistant pathogens were extended-spectrum cephalosporin-resistant E. coli (37.1%), extended spectrum cephalosporin-resistant Klebsiella (27.8%), carbapenem-non-susceptible Acinetobacter spp. (19.5%), carbapenem-non-susceptible Pseudomonas aeruginosa (19.2%) and methicillin-resistant S. aureus (18.6%). Conclusion: National collaboration is required by prompt feedback to local authorities to tackle regional differences in AMR. This can help plan timely containment interventions to stop and contain microbial threats and swiftly assess their impact. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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收藏
页码:142 / 150
页数:9
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