Two new cytotoxic steroids from the Chinese soft coral Sinularia sp.

被引：25

作者：

Li, Song-Wei ^{[1
,2
]}

Chen, Wen-Ting ^{[2
]}

Yao, Li-Gong ^{[2
]}

Guo, Yue-Wei ^{[2
]}

机构：

[1] Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangiiang Hitech Pk, Shanghai 201203, Peoples R China

来源：

STEROIDS | 2018年 / 136卷

关键词：

Sinularia; Polyhydroxylated steroids; Modified Mosher's method; Cytotoxicity; POLYOXYGENATED STEROIDS; PHARMACOLOGICAL-ACTIVITIES; POLYHYDROXYLATED STEROIDS;

D O I：

10.1016/j.steroids.2018.05.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new steroids, ximaosteroid E (1) and ximaosteroid F (2), along with two known related compounds (3 and 4), were isolated from the Chinese soft coral Sinularia sp. Notably, 1 possesses an uncommon dihydrofuran group. Their structures were established from extensive spectroscopic analyses and comparisons of their spectral data with those reported in the literature. The absolute configuration of 2 was determined by applying the modified Mosher's method. In bioassay, compounds 1, 2, and 4 showed significant cytotoxicity against the HL-60 tumor cell line with IC50 values of 1.79, 4.03 and 0.69 mu M, respectively.

引用

页码：17 / 21

页数：5

共 15 条

[1] Further study on synthesis and evaluation of 3,16,20-polyoxygenated steroids of marine origin and their analogs as potent cytotoxic agents [J].