Concomitant Evaluation of Heart Period and QT Interval Variability Spectral Markers to Typify Cardiac Control in Humans and Rats

被引:13
作者
De Maria, Beatrice [1 ]
Bari, Vlasta [2 ]
Sgoifo, Andrea [3 ,4 ]
Carnevali, Luca [3 ,4 ]
Cairo, Beatrice [5 ]
Vaini, Emanuele [2 ]
Catai, Aparecida Maria [6 ]
de Medeiros Takahashi, Anielle Cristhine [6 ]
Dalla Vecchia, Laura Adelaide [1 ]
Porta, Alberto [2 ,5 ]
机构
[1] IRCCS Ist Clin Sci Maugeri, Milan, Italy
[2] IRCCS Policlin San Donato, Dept Cardiothorac Vasc Anesthesia & Intens Care, Milan, Italy
[3] Univ Parma, Stress Physiol Lab, Dept Chem Life Sci & Environm Sustainabil, Parma, Italy
[4] Univ Parma, Microbiome Res Hub, Parma, Italy
[5] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy
[6] Univ Fed Sao Carlos, Dept Physiotherapy, Sao Carlos, SP, Brazil
关键词
power spectral analysis; heart rate variability; QTV; ventricular repolarization; autonomic nervous system; wild-type rat; Wistar; head-up tilt; SYMPATHETIC-NERVE ACTIVITY; R-T INTERVAL; VENTRICULAR REPOLARIZATION; SOCIAL STRESS; CARDIOVASCULAR VARIABILITY; SYMPATHOVAGAL BALANCE; AUTONOMIC MODULATION; UP TILT; ECG; SYSTEM;
D O I
10.3389/fphys.2019.01478
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The variability of heart period, measured as the time distance between two consecutive QRS complexes from the electrocardiogram (RR), was exploited to infer cardiac vagal control, while the variability of the duration of the electrical activity of the heart, measured as the time interval from Q-wave onset to T-wave end (QT), was proposed as an indirect index of cardiac sympathetic modulation. This study tests the utility of the concomitant evaluation of RR variability (RRV) and QT variability (QTV) markers in typifying cardiac autonomic control of humans under different experimental conditions and of rat groups featuring documented differences in resting sympatho-vagal balance. We considered: (i) 23 healthy young subjects in resting supine position (REST) undergoing head-up tilt at 45 degrees (T45) and 90 degrees (T90) followed by recovery to the supine position; (ii) 9 Wistar (WI) and 14 wild-type Groningen (WT) rats in unstressed conditions, where the WT animals were classified as non-aggressive (non-AGG, n = 9) and aggressive (AGG, n = 5) according to the resident intruder test. In humans, spectral analysis of RRV and QTV was performed over a single stationary sequence of 250 consecutive values. In rats, spectral analysis was iterated over 10-min recordings with a frame length of 250 beats with 80% overlap and the median of the distribution of the spectral markers was extracted. Over RRV and QTV we computed the power in the low frequency (LF, from 0.04 to 0.15 Hz in humans and from 0.2 to 0.75 Hz in rats) band (LFRR and LFQT) and the power in the high frequency (HF, from 0.15 to 0.5 Hz in humans and from 0.75 to 2.5 Hz in rats) band (HFRR and HFQT). In humans the HFRR power was lower during T90 and higher during recovery compared to REST, while the LFQT power was higher during T90. In rats the HFRR power was lower in WT rats compared to WI rats and the LFQT power was higher in AGG than in non-AGG animals. We concluded that RRV and QTV provide complementary information in describing the functioning of vagal and sympathetic limbs of the autonomic nervous system in humans and rats.
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页数:12
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